---
title: "Glycemic Index and CVD: a Crossover Feeding Study"
nct_id: NCT00141076
overall_status: COMPLETED
phase: NA
sponsor: "Boston Children's Hospital"
study_type: INTERVENTIONAL
primary_condition: Obesity
countries: United States
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT00141076.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT00141076"
ct_last_update_post_date: 2010-08-30
last_seen_at: "2026-05-12T06:49:44.685Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Glycemic Index and CVD: a Crossover Feeding Study

**Official Title:** Glycemic Index, Obesity, Insulin Resistance and CVD Risk, Part 2

**NCT ID:** [NCT00141076](https://clinicaltrials.gov/study/NCT00141076)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 24
- **Lead Sponsor:** Boston Children's Hospital
- **Collaborators:** National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Charles H. Hood Foundation
- **Conditions:** Obesity
- **Start Date:** 2003-10
- **Completion Date:** 2006-07
- **CT.gov Last Update:** 2010-08-30

## Brief Summary

This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese adults in a 10-day crossover feeding trial.

## Detailed Description

This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 35 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* age 18 to 35 years
* male
* BMI ≥ 27 ≤45 kg/m2
* willingness to refrain from alcohol and caffeinated beverage consumption for duration of study

Exclusion Criteria:

* major medical illness
* an abnormal screening laboratory test
* taking any prescription medications that might affect body weight
* current smoking (1 cigarette during any of the last 7 days)
* consuming special diets
```

## Interventions

- **low vs high glycemic index diet** (BEHAVIORAL)

## Primary Outcomes

- **Insulin sensitivity as measured by FS-IVGTT**

## Secondary Outcomes

- **CVD risk factors**
- **Postprandial studies of oxidative stress**
- **Thermic effect of food**

## Locations (1)

- Brigham & Women's Hospital, Boston, Massachusetts, United States

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.brigham & women's hospital|boston|massachusetts|united states` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT00141076*  
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