---
title: A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection
nct_id: NCT00216853
overall_status: COMPLETED
sponsor: "London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's"
study_type: OBSERVATIONAL
primary_condition: Urinary Tract Infections
countries: Canada
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT00216853.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT00216853"
ct_last_update_post_date: 2009-04-16
last_seen_at: "2026-05-12T07:11:24.485Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# A Study of Vaginal MicroFlora and Immune Profiles of Patients With Recurrent Urinary Tract Infection

**NCT ID:** [NCT00216853](https://clinicaltrials.gov/study/NCT00216853)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 44
- **Lead Sponsor:** London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- **Collaborators:** Natural Sciences and Engineering Research Council, Canada
- **Conditions:** Urinary Tract Infections
- **Start Date:** 2003-09
- **Completion Date:** 2007-03
- **CT.gov Last Update:** 2009-04-16

## Brief Summary

The purpose of this study is to determine the extent to which vaginal microflora and immune profiles of patients with urinary tract infection (UTI) differ from healthy controls.

## Detailed Description

Recurrent urinary tract infections, which occur mostly in the female population, can be potentially harmful if not treated and significantly reduce quality of life. By characterizing the vaginal microflora and immune profiles of women that suffer recurrent UTIs in contrast to a healthy age matched normal group of women (with no history of recurrent UTIs), we can better understand the differences. This in turn can lead to development of better quality probiotics that will be based on their scientific basis, clinical efficacy, and quality in terms of shelf life and delivery to target sites. The reduction in only one third of UTI cases seen each year would have a significant impact on reducing health care costs.

## Eligibility

- **Minimum age:** 20 Years
- **Maximum age:** 80 Years
- **Sex:** FEMALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

Inclusion Criteria for UTI Group:

1. At least 2 recurrent UTIs within the last year
2. Written informed consent

Inclusion Criteria for Normal Group:

1. No UTI within the past 5 years
2. Written informed consent

Exclusion Criteria:

Exclusion Criteria for Both Groups:

1. Active UTI
2. Urinary tract anomalies
3. Evidence of a neurogenic bladder
4. Known immunodeficiencies
5. Use of antibiotics, within the last month
6. Concomitant use of oral steroids
7. Known renal calculi
8. Previous or ongoing chemotherapy
9. Pregnancy
```

## Arms

- **Patients with Recurrent UTI**
- **Healthy controls**

## Locations (1)

- St. Joseph's Health Centre, London, Ontario, Canada

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.st. joseph's health centre|london|ontario|canada` — added _(2026-05-12)_

---

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