---
title: Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy
nct_id: NCT00242060
overall_status: COMPLETED
phase: NA
sponsor: University Health Network, Toronto
study_type: INTERVENTIONAL
primary_condition: Elevated PSA
countries: Canada
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT00242060.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT00242060"
ct_last_update_post_date: 2010-07-15
last_seen_at: "2026-05-12T06:55:13.513Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy

**Official Title:** The Utility of Functional and Morphologic MRI in the Detection of Prostate Cancer for Patients With Elevated PSA and Prior Negative Biopsy

**NCT ID:** [NCT00242060](https://clinicaltrials.gov/study/NCT00242060)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Lead Sponsor:** University Health Network, Toronto
- **Conditions:** Elevated PSA, Prostate Cancer
- **Start Date:** 2002-11
- **Completion Date:** 2008-11
- **CT.gov Last Update:** 2010-07-15

## Brief Summary

Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for prostate cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound guided biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent elevated PSA and may harbor occult prostate cancer. The purpose of this study is to determine if MRI using an endorectal coil, and advanced MRI methods called H1 MR Spectroscopy (MRS) and Dynamic MR Perfusion Imaging (dMRI) can help identify and localize prostate cancer in these patients and direct repeat TRUS-Bx to the most suspicious location in the prostate gland. 100 men, currently under observation with elevated PSA but negative TRUS-Bx will be enrolled in the study.

## Detailed Description

Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for prostate cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound guided biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent elevated PSA and may harbor occult prostate cancer. The purpose of this study is to determine if MRI using an endorectal coil, and advanced MRI methods called H1 MR Spectroscopy (MRS) and Dynamic MR Perfusion Imaging (dMRI) can help identify and localize prostate cancer in these patients and direct repeat TRUS-Bx to the most suspicious location in the prostate gland. 100 men, currently under observation with elevated PSA but negative TRUS-Bx will be enrolled in the study.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** MALE
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* prior ultrasound biopsy of prostate showing no cancer or only single microfocus of cancer

Exclusion Criteria:

* contraindication to contrast enhanced endorectal coil MRI
```

## Interventions

- **MRI** (PROCEDURE)

## Locations (1)

- University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.university health network, princess margaret hospital|toronto|ontario|canada` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT00242060.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT00242060*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*