---
title: The Association of Genetic Polymorphisms With Statin-Induced Myopathy.
nct_id: NCT00549029
overall_status: UNKNOWN
sponsor: National Taiwan University Hospital
study_type: OBSERVATIONAL
primary_condition: Rhabdomyolysis
countries: Taiwan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT00549029.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT00549029"
ct_last_update_post_date: 2007-10-25
last_seen_at: "2026-05-12T06:24:27.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# The Association of Genetic Polymorphisms With Statin-Induced Myopathy.

**Official Title:** Association Analysis Between Single Nucleotide Polymorphisms in Statin-Related Genes and The Incidence of Myopathy Among Statin-Treated Patients

**NCT ID:** [NCT00549029](https://clinicaltrials.gov/study/NCT00549029)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 150
- **Lead Sponsor:** National Taiwan University Hospital
- **Conditions:** Rhabdomyolysis, Myopathy
- **Start Date:** 2007-08
- **Completion Date:** 2008-01
- **CT.gov Last Update:** 2007-10-25

## Brief Summary

To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of statins-induced myopathy.

## Detailed Description

Statins are widely prescribed for the patients with hypercholesterolemia.

Though their efficacy in preventing cardiovascular events has been shown by a large number of clinical trials, myotoxic side effects including myopathy or even more severe,rhabdomyolysis are associated with the use of statins.

Because the incidence of myopathy is various among individuals,polymorphism in genes is supposed to be the main factor.

Due to single nucleotide polymorphism in related genes,level of uptake, clearance and metabolism of statins can be seriously different among individuals resulting in various occurrence of myopathy.

Therefore, analytical study in association between SNP of statins-related genes and the incidence of myopathy is such a critical research which can be applied into clinical fields.

## Eligibility

- **Minimum age:** 21 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Clinical diagnosis of Rhabdomyolysis because of prescription with statins

Exclusion Criteria:

* Carnitine palmityl transferase ll deficiency
* McArdle disease
* Myoadenylate deaminase deficiency
```

## Arms

- **1,2** — Group 1 for the patients with rhabdomyolysis Group 2 for the control without any myopathy

## Interventions

- **DNA** (GENETIC) — withdraw 5\~10mL blood from vein only once during the whole design

## Primary Outcomes

- **genotype of specific genes** _(time frame: one day)_

## Secondary Outcomes

- **single nucleotide polymorphism** _(time frame: one day)_

## Locations (1)

- National Taiwan University Hospital, Taipei, Taiwan — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.national taiwan university hospital|taipei||taiwan` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT00549029*  
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