---
title: Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure
nct_id: NCT01102790
overall_status: UNKNOWN
sponsor: Johann Wolfgang Goethe University Hospital
study_type: OBSERVATIONAL
primary_condition: Heparin-Induced Thrombocytopenia
countries: Germany
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01102790.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01102790"
ct_last_update_post_date: 2010-04-15
last_seen_at: "2026-05-12T06:05:41.685Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure

**Official Title:** Generation of HIT-antibodies Without Prior Heparin Exposure Following Orthopedic Surgery (Subgroup Study) (Change of Coagulation Parameters Under Exposition With New Anticoagulants [Title of the Main Study])

**NCT ID:** [NCT01102790](https://clinicaltrials.gov/study/NCT01102790)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 160
- **Lead Sponsor:** Johann Wolfgang Goethe University Hospital
- **Conditions:** Heparin-Induced Thrombocytopenia, Thrombosis
- **Start Date:** 2010-04
- **Completion Date:** 2010-10
- **CT.gov Last Update:** 2010-04-15

## Brief Summary

The purpose of this study is to determine the HIT-antibody generation without prior heparin-exposure in patients undergoing orthopedic surgery.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Major orthopedic surgery

Exclusion Criteria:

* Heparin exposure
* Infection
```

## Primary Outcomes

- **incidence of HIT-antibodies** _(time frame: between day 5 and day 14 after surgery)_

## Secondary Outcomes

- **thromboembolic events** _(time frame: up to 21 days after surgery)_

## Locations (1)

- J.W.Goethe University Hospital Frankfurt/M., Frankfurt am Main, Hesse, Germany — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.j.w.goethe university hospital frankfurt/m.|frankfurt am main|hesse|germany` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01102790.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01102790*  
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