---
title: Characterization and Differential Diagnosis of Vertebral Osteomyelitis
nct_id: NCT01125839
overall_status: COMPLETED
sponsor: Asan Medical Center
study_type: OBSERVATIONAL
primary_condition: Vertebral Osteomyelitis
countries: South Korea
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01125839.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01125839"
ct_last_update_post_date: 2014-02-25
last_seen_at: "2026-05-12T07:13:47.285Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Characterization and Differential Diagnosis of Vertebral Osteomyelitis

**Official Title:** Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis

**NCT ID:** [NCT01125839](https://clinicaltrials.gov/study/NCT01125839)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 100
- **Lead Sponsor:** Asan Medical Center
- **Conditions:** Vertebral Osteomyelitis
- **Start Date:** 2010-05
- **Completion Date:** 2013-12
- **CT.gov Last Update:** 2014-02-25

## Brief Summary

Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

## Detailed Description

Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.

## Eligibility

- **Minimum age:** 16 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Symptoms or signs consistent with spinal column infection
* MRI findings suggestive of infection
* Antibiotic treatment for vertebral myelitis

Exclusion Criteria:

* Patients already treated more than 2 weeks for osteomyelitis in transferring hospital
```

## Arms

- **Spondylitis** — Patients who checked spine MRI for back pain

## Primary Outcomes

- **Identification of etiology of vertebral osteomyelitis** _(time frame: within 6 weeks after the diagnosis of vertebral osteomyelitis)_

## Secondary Outcomes

- **Unfavorable outcomes (death or permanent neurologic deficit)** _(time frame: within 6 months after the diagnosis of vertebral osteomyelitis)_

## Locations (1)

- Asan Medical Center, Seoul, South Korea

## Recent Field Changes (last 30 days)

- `locations.asan medical center|seoul||south korea` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01125839.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01125839*  
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