---
title: Incidence of Occluded Culprit Arteries and Impact of Coronary Collaterals on Outcome in Patients With NSTEMI
nct_id: NCT01159366
overall_status: COMPLETED
phase: PHASE4
sponsor: University of Jena
study_type: INTERVENTIONAL
primary_condition: NSTEMI
countries: Germany
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01159366.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01159366"
ct_last_update_post_date: 2010-07-12
last_seen_at: "2026-05-12T06:22:24.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Incidence of Occluded Culprit Arteries and Impact of Coronary Collaterals on Outcome in Patients With NSTEMI

**Official Title:** Substudy of the Leipzig Immediate Versus Early and Late Percutaneous Coronary Intervention Trial in NSTEMI - LIPSIA-NSTEMI TRIAL

**NCT ID:** [NCT01159366](https://clinicaltrials.gov/study/NCT01159366)

## Key Facts

- **Status:** COMPLETED
- **Phase:** PHASE4
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 602
- **Lead Sponsor:** University of Jena
- **Conditions:** NSTEMI
- **Start Date:** 2006-07
- **Completion Date:** 2010-01
- **CT.gov Last Update:** 2010-07-12

## Brief Summary

It is assumed that patients with non-ST-elevation myocardial infarctions (NSTEMI) showing an infero- or posterolateral occluded culprit artery (OCA) during diagnostic angiography frequently elude standard 12-lead electrocardiogram diagnosis. In addition, coronary collaterals may have beneficial effects in patients with OCA.

## Detailed Description

We examined consecutive NSTEMI patients within 48 h of symptom onset. All patients underwent early invasive angiography plus optimal medical therapy. We compared baseline characteristics, procedural findings including analysis of TIMI-flow and collaterals using the Rentrop-classification, 30-day and 6-months major adverse cardiovascular events (MACE) in patients with and without totally OCA.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 90 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* age between 18 and 90 years,
* onset of angina pectoris at rest \<24 h or crescendo angina in recent weeks with symptoms under minimal exertion or at rest lasting \<24 h,
* elevated troponin T ≥0.03 µg/L and
* written informed consent.

Exclusion Criteria:

* persistent angina,
* ST-segment elevation myocardial infarction (STEMI),
* hemodynamic instability including cardiogenic shock,
* oral anticoagulation therapy,
* contraindications for glycoprotein IIb/IIIa inhibitors,
* other disease with life expectancy \<6 months,
* known coagulopathy,
* pregnancy,
* other suspected causes of troponin elevation as myocarditis, secondary to hypertensive crisis, or after cardiac decompensation,
* no ability to consent, and
* participation in another study.
```

## Arms

- **occluded culprit artery** (ACTIVE_COMPARATOR) — An occluded lesion was defined as a lesion with 100% stenosis or TIMI-flow grade 0 or 1.
- **non-occluded culprit artery** (ACTIVE_COMPARATOR) — A non-occluded lesion was defined as a lesion without 100% stenosis or TIMI-flow grade 0 or 1.

## Interventions

- **percutaneous coronary intervention** (PROCEDURE) — early timing

## Primary Outcomes

- **MACE** _(time frame: 6 months)_ — composite of death, reinfarction and readmission for unstable angina within 6 months after inclusion

## Secondary Outcomes

- **CK and CK-MB** _(time frame: 48 hours)_

## Locations (1)

- University of Leipzig, Leipzig, Germany

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.university of leipzig|leipzig||germany` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01159366.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01159366*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*