---
title: Investigation of Biomarkers in Susac Syndrome
nct_id: NCT01273792
overall_status: UNKNOWN
sponsor: Charite University, Berlin, Germany
study_type: OBSERVATIONAL
primary_condition: Susac Syndrome
countries: Germany
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01273792.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01273792"
ct_last_update_post_date: 2021-07-29
last_seen_at: "2026-05-12T06:33:03.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Investigation of Biomarkers in Susac Syndrome

**Official Title:** Investigation of Relevant Biomarkers in Patients With Susac Syndrome

**NCT ID:** [NCT01273792](https://clinicaltrials.gov/study/NCT01273792)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 30
- **Lead Sponsor:** Charite University, Berlin, Germany
- **Conditions:** Susac Syndrome
- **Start Date:** 2010-05
- **Completion Date:** 2021-12
- **CT.gov Last Update:** 2021-07-29

## Brief Summary

Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome

## Detailed Description

Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed.

The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated.

Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* adult male and female patients with definite Susac syndrome or matching healthy control subjects
* ability to provide informed consent

Exclusion Criteria:

* pregnancy
```

## Arms

- **Patients with Susac syndrome**
- **Matched healthy controls**

## Primary Outcomes

- **disease specific patterns of pathology on cranial MRI** — one-time cranial MRI
- **disease specific patterns of pathology in optical coherence tomography** — one time optical coherence tomography
- **serological biomarkers** _(time frame: not defined, cross-sectional analysis)_

## Locations (1)

- NeuroCure Clinical Reserach Center, Charité Universitaetsmedizin, Berlin, Germany — _RECRUITING_

## Recent Field Changes (last 30 days)

- `outcomes.primary` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.neurocure clinical reserach center, charité universitaetsmedizin|berlin||germany` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01273792.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01273792*  
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