---
title: Changes in the Distribution of Mitochondria During Oocyte Maturation
nct_id: NCT01501292
overall_status: UNKNOWN
sponsor: Hillel Yaffe Medical Center
study_type: OBSERVATIONAL
primary_condition: Infertility
countries: Israel
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01501292.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01501292"
ct_last_update_post_date: 2011-12-29
last_seen_at: "2026-05-12T07:20:43.885Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Changes in the Distribution of Mitochondria During Oocyte Maturation

**NCT ID:** [NCT01501292](https://clinicaltrials.gov/study/NCT01501292)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 20
- **Lead Sponsor:** Hillel Yaffe Medical Center
- **Conditions:** Infertility
- **Start Date:** 2012-01
- **Completion Date:** 2012-04
- **CT.gov Last Update:** 2011-12-29

## Brief Summary

Cytoplasmatic maturation is an important event in the general maturation of of the oocyte. Mitochondria is one of the major organelles involved in the process of cytoplasmatic maturation. The aim of this study is to investigate the presence and distribution of the mitochondria in the cytoplasma of immature oocytes that are retrieved in the routine in-vitro maturation cycle with intracytoplasmatic sperm injection (ICSI). These oocytes will not undergo ICSI because of their immaturity. Usually, they are discarded. In addition to these immature oocytes the investigators shall also investigate the mitochondria in mature oocytes that underwent ICSI but did not become fertilized and are discarded.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 44 Years
- **Sex:** FEMALE
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Infertile patients needing IVF treatment

Exclusion Criteria:

* Patients not requiring the ICSI procedure
```

## Arms

- **Immature oocytes (GV, M-I)**
- **Mature oocytes (M-II)**

## Interventions

- **Fixation and staining** (OTHER) — Fixation and staining by MitiTracker Green FM
- **Observation by laser microscopy** (OTHER) — Observation with Laser scanning confocal microscopy

## Primary Outcomes

- **The patterns of mitochondrial distribution within the cytoplasma of oocytes during nuclear maturation** _(time frame: Three months)_ — Identification the different patterns of mitochondrial distribution in correlation with the 3 stages nuclear maturation in human oocytes

## Locations (1)

- Hillel Yaffe Medical Center, Hadera, Israel

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.hillel yaffe medical center|hadera||israel` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01501292.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01501292*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*