---
title: Postoperative Desogestrel for Endometriosis Related Pain
nct_id: NCT01559480
overall_status: COMPLETED
phase: NA
sponsor: Mahidol University
study_type: INTERVENTIONAL
primary_condition: Endometriosis
countries: Thailand
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01559480.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01559480"
ct_last_update_post_date: 2015-04-09
last_seen_at: "2026-05-12T06:58:48.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Postoperative Desogestrel for Endometriosis Related Pain

**Official Title:** A Prospective Double Blind Randomized Controlled Trial to Study the Effectiveness of a Desogestrel for the Treatment of Pelvic Pain or Dysmenorrhea in the Patients Undergone Conservative Surgery for Pelvic Endometriosis

**NCT ID:** [NCT01559480](https://clinicaltrials.gov/study/NCT01559480)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 40
- **Lead Sponsor:** Mahidol University
- **Conditions:** Endometriosis
- **Start Date:** 2012-01
- **Completion Date:** 2014-10
- **CT.gov Last Update:** 2015-04-09

## Brief Summary

Endometriosis is one of the most common disease in reproductive aged women.Surgical intervention has a significant symptoms relief. However, symptom recurrence is often after surgery. This study aims to determine the efficacy of Desogestrel compared with placebo in pain symptom of symptomatic endometriosis patient undergo conservative surgery . The primary outcome measurement is pain score at 6 months after surgery.

## Detailed Description

After conservative surgery, the patients are randomized to Desogestrel and placebo groups. VAS pain score are compared after complete 6 months

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 45 Years
- **Sex:** FEMALE
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* diagnoses endometriosis
* Plan conservative surgery
* initial pain score at least 5
* voluntary to be the participant of this study with inform consent
* No desired child bearing in 6 months

Exclusion Criteria:

* residual lesion after surgery which required further treatment
* cannot participate complete 6 months after surgery
* contraindication for Desogestrel, Paracetamol or Ponstan
* Pregnant
```

## Arms

- **Desogestrel** (ACTIVE_COMPARATOR)
- **Placebo** (PLACEBO_COMPARATOR)

## Interventions

- **Desogestrel** (DRUG) — Desogestrel 75 mcg Takes 1 capsule before bedtime for 6 months
- **Placebo** (DRUG) — Placebo capsule takes 1 capsule before bedtime for 6 months

## Primary Outcomes

- **Pain score** _(time frame: 6 months)_ — Pain score will be assessed by visual analog scale (0-10)

## Secondary Outcomes

- **Side effect compared between both group** _(time frame: 6 month)_
- **Patients satisfaction compare between both groups** _(time frame: 6 months)_

## Locations (2)

- Faculty of medicine Siriraj hospital, Mahidol university, Bangkok Noi, Bangkok, Thailand
- Siriraj hospital Mahidol university, Bangkok Noi, Bangkok, Thailand

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.faculty of medicine siriraj hospital, mahidol university|bangkok noi|bangkok|thailand` — added _(2026-05-12)_
- `locations.siriraj hospital mahidol university|bangkok noi|bangkok|thailand` — added _(2026-05-12)_

---

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