---
title: Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke
nct_id: NCT01655160
overall_status: COMPLETED
phase: NA
sponsor: Chang Gung Memorial Hospital
study_type: INTERVENTIONAL
primary_condition: Cerebrovascular Accident
countries: Taiwan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01655160.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01655160"
ct_last_update_post_date: 2015-06-08
last_seen_at: "2026-05-12T06:08:54.414Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke

**Official Title:** Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke: Outcomes in Brain and Movement Reorganization, Sensorimotor and Daily Functions, and Measures of Physiological Markers.

**NCT ID:** [NCT01655160](https://clinicaltrials.gov/study/NCT01655160)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 2
- **Lead Sponsor:** Chang Gung Memorial Hospital
- **Collaborators:** National Science and Technology Council, Taiwan
- **Conditions:** Cerebrovascular Accident
- **Start Date:** 2012-08
- **Completion Date:** 2015-03
- **CT.gov Last Update:** 2015-06-08

## Brief Summary

The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.

## Detailed Description

This trial is to examine whether (1) the immediate effects of treatment intensity in MT would occur on sensorimotor impairments and functional performance in patients with subacute stroke; (2) the long-term benefits of treatment intensity in MT on functionality can persist for six months after treatment finished; and (3) the MT could result in cortical/movement reorganization as well as the changes in physiological markers.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* first episode of stroke in cortical regions
* time since stroke less than 3 months
* initial motor part of UE of FMA score ranging from 24 to 52
* no serious cognitive impairment

Exclusion Criteria:

* aphasia
* visual impairments
* major health problems or poor physical conditions
* currently participation in any other
```

## Arms

- **mirror therapy treatment** (EXPERIMENTAL) — Three groups will be involved in this part of the whole project:MT with low-intensity group (MT-LI), MT with moderate-intensity group (MT-MI), MT with high-intensity group (MT-HI)
- **control intervention group** (ACTIVE_COMPARATOR) — The part of this project will involve 1 treatment groups:control intervention group (CI)

## Interventions

- **MT with low-intensity group (MT-LI)** (BEHAVIORAL) — The MT-LI group will receive a 30-minute MT per session followed by a 30-minute functional training.
- **MT with moderate-intensity group** (BEHAVIORAL) — The MT-MI group will receive a 60-minute MT per session followed by a 30-minute functional training.
- **Mirror therapy with high intensity group** (BEHAVIORAL) — The MT-HI group will receive a 90-minute MT per session followed by a 30-minute functional training
- **Control intervention group** (BEHAVIORAL) — The CI group will carry out a 30-minute conventional stroke rehabilitation training per session followed by a 30-minute functional training.

## Primary Outcomes

- **Fugl-Meyer Assessment (FMA)** _(time frame: Baseline, change from baseline in FMA at 2 weeks, and change from baseline in FMA at 4 weeks)_ — The UE subscale of the FMA (max. score 66) uses a 3-point ordinal scale to assess motor impairment.
- **Action Research Arm Test (ARAT)** _(time frame: Baseline, change of ARAT at 2 weeks, and change of ARAT at 4 weeks)_ — ARAT will be used to assess the motor function of UE. A total of 19 items are to test the movement of grasp, grip, pinch, and gross motor, with a scale of 0-3 for each item (maximal of 57).
- **Motor Activity Log (MAL)** _(time frame: Baseline, change of MAL at 2 weeks, and change of MAL at 4 weeks)_ — The MAL is a semi-structured interview of patients to assess the amount of use (AOU) and quality of movement (QOM) of the affected upper extremity in 30 important daily activities using a 6-point ordinal scale. Higher scores indicate better performance.
- **ABILHAND Questionnaire** _(time frame: Baseline, change of ABILHAND Questionnaire at 2 weeks, and change of ABILHAND Questionnaire at 4 weeks)_ — ABILHAND questionnaire is an inventory of 56 manual activities that uses a 3-point ordinal scale to measure subjectively perceived difficulty in performing everyday bimanual activity.
- **Adelaide Activities Profile (AAP)** _(time frame: Baseline, change of AAP at 2 weeks, and change of AAP at 4 weeks)_ — AAP will be applied to indicate the level of participation in household and community activities. This profile includes 21 activities in the four areas: domestic chores, household maintenance, service to others, and social activities.

## Secondary Outcomes

- **Functional magnetic resonance imaging (fMRI)** _(time frame: Baseline and change of fMRI at 4 weeks)_
- **Physiological marker measures** _(time frame: Baseline and change from baseline in physiological marker measures at 4 weeks)_

## Locations (1)

- Chang Gung Memorial Hospital, Kwei-shan, Toayuan County, Taiwan

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.chang gung memorial hospital|kwei-shan|toayuan county|taiwan` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01655160.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01655160*  
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