---
title: Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia
nct_id: NCT01710280
overall_status: COMPLETED
phase: NA
sponsor: "King's College London"
study_type: INTERVENTIONAL
primary_condition: Healthy Men
countries: United Kingdom
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01710280.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01710280"
ct_last_update_post_date: 2019-09-16
last_seen_at: "2026-05-12T06:12:45.013Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

**NCT ID:** [NCT01710280](https://clinicaltrials.gov/study/NCT01710280)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 11
- **Lead Sponsor:** King's College London
- **Conditions:** Healthy Men, Raised Fasting Plasma Triacylglycerol Concentrations
- **Start Date:** 2011-05
- **Completion Date:** 2012-06
- **CT.gov Last Update:** 2019-09-16

## Brief Summary

The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

## Eligibility

- **Minimum age:** 40 Years
- **Maximum age:** 70 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Healthy males
* Non-smokers
* Aged 40-70 years
* Fasting TAG concentrations ≥1.5 mmol/L.

Exclusion Criteria:

* Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
* Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
* History of substance abuse or alcoholism (previous weekly alcohol intake \>60 units/men)
* Current self-reported weekly alcohol intake exceeding 28 units
* Allergy or intolerance to any component of test meals
* Unwilling to restrict consumption of any source of fish oil for the length of the study
* Weight change of \>3kg in preceding 2 months
* Body Mass Index \<20 and \>35 kg/m2
* Fasting blood cholesterol \> 7.8 mmol/L
* Current cigarette smoker.
* Current use of lipid lowering medication
```

## Arms

- **Native palm olein** (ACTIVE_COMPARATOR) — 75 g native palm olein
- **Interesterified palm olein** (EXPERIMENTAL) — 75 g interesterified palm olein

## Interventions

- **High-fat meal containing native palm olein** (DIETARY_SUPPLEMENT)
- **High-fat meal containing interesterified palm olein** (DIETARY_SUPPLEMENT)

## Primary Outcomes

- **Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations** _(time frame: 1-6 h post-meal)_

## Secondary Outcomes

- **Incremental AUC for plasma non-esterified fatty acid concentrations** _(time frame: 1-6 h post-meal)_
- **Changes from baseline in digital volume pulse** _(time frame: 2,4,5,6 h post-meal)_
- **Changes from baseline in blood pressure** _(time frame: 2,4,5,6 h post-meal)_

## Locations (1)

- Diabetes & Nutritional Sciences Division, King's College London., London, United Kingdom

## Recent Field Changes (last 30 days)

- `design.enrollmentCount` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.diabetes & nutritional sciences division, king's college london.|london||united kingdom` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01710280.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01710280*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*