---
title: Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism
nct_id: NCT01770548
overall_status: COMPLETED
phase: NA
sponsor: University Hospital, Tours
study_type: INTERVENTIONAL
primary_condition: Autism
countries: France
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01770548.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01770548"
ct_last_update_post_date: 2017-01-16
last_seen_at: "2026-05-12T06:44:38.813Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism

**Official Title:** Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.

**NCT ID:** [NCT01770548](https://clinicaltrials.gov/study/NCT01770548)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 497
- **Lead Sponsor:** University Hospital, Tours
- **Conditions:** Autism
- **Start Date:** 2009-01
- **Completion Date:** 2014-06
- **CT.gov Last Update:** 2017-01-16

## Brief Summary

Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism

## Detailed Description

Analysis about 50 genes in glutamate synapse

## Eligibility

- **Minimum age:** 2 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* have a Pervasive Developmental Disorder

Exclusion Criteria:

* N/A
```

## Arms

- **Autism** (EXPERIMENTAL) — Analysis of the glutamate synapse in autism
- **Relative** (OTHER) — Analysis of the glutamate synapse in autism
- **Major control** (OTHER) — DNA collection
- **Minor control** (OTHER) — auditory evoked potentials

## Interventions

- **analysis of the glutamate synapse in autism** (GENETIC) — Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
- **DNA collection** (GENETIC) — DNA collection
- **Auditory evoked potentials** (OTHER) — auditory evoked potentials

## Primary Outcomes

- **screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients** _(time frame: two years)_

## Locations (4)

- CHRU - Centre de Ressources Autisme (CRA), Brest, France
- CHS du ROUVRAY, Rouen, France
- Chru - Cic, Tours, France
- CHRU - Pédopsychiatrie, Tours, France

## Recent Field Changes (last 30 days)

- `results.hasResults` — added _(2026-05-12)_
- `locations.chru - centre de ressources autisme (cra)|brest||france` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `locations.chs du rouvray|rouen||france` — added _(2026-05-12)_
- `locations.chru - cic|tours||france` — added _(2026-05-12)_
- `locations.chru - pédopsychiatrie|tours||france` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01770548.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01770548*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*