---
title: Respirophasic Carotid Artery Peak Velocity Variation as a Predictor of Fluid Responsiveness in Patients With Coronary Disease
nct_id: NCT01836081
overall_status: COMPLETED
phase: NA
sponsor: Yonsei University
study_type: INTERVENTIONAL
primary_condition: Coronary Artery Occlusive Disease
countries: South Korea
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01836081.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01836081"
ct_last_update_post_date: 2013-04-19
last_seen_at: "2026-05-12T06:29:58.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Respirophasic Carotid Artery Peak Velocity Variation as a Predictor of Fluid Responsiveness in Patients With Coronary Disease

**NCT ID:** [NCT01836081](https://clinicaltrials.gov/study/NCT01836081)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 40
- **Lead Sponsor:** Yonsei University
- **Conditions:** Coronary Artery Occlusive Disease
- **Start Date:** 2011-12
- **Completion Date:** 2012-12
- **CT.gov Last Update:** 2013-04-19

## Brief Summary

The aim of this study is to investigate usefulness of the respirophasic variation in carotid artery peak flow velocity measured by Doppler ultrasound, which is noninvasive and easily accessible, as a predictor of fluid responsiveness in patients with coronary artery disease.

## Eligibility

- **Minimum age:** 20 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

1\. patients scheduled for elective isolated off-pump coronary artery bypass graft surgery

Exclusion Criteria:

1. cardiac rhythm other than sinus
2. congestive heart failure
3. left ventricular ejection fraction \<35%
4. history of transient ischemic attack
5. pre-existing cerebrovascular disease and peripheral arterial occlusive disease
6. presence of carotid artery stenosis \>50%
```

## Arms

- **fluid responsiveness** (EXPERIMENTAL)

## Interventions

- **Volume expansion** (OTHER)

## Primary Outcomes

- **Predictive power of the respirophasic carotid flow peak velocity variation for the fluid responsiveness** _(time frame: Measurement of respirophasic carotid flow peak velocity variation before the volume expansion)_ — After induction of anesthesia, peak velocity of carotid artery blood flow is measured by the pulsed wave Doppler signal obtained from the left common carotid artery. Respirophasic variation of the peak velocity is defined as the difference between the maximum and the minimum values of peak velocity divided by the mean of the two values during one respiratory cycle. Fluid responder is defined as a patient whose stroke volume index is increased ≥15% after volume expansion. The receiver operating characteristic curve analysis to descriminiate fluid responder is performed.

## Locations (1)

- Yonsei University College of Medicine, Seoul, Seoul, South Korea

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.yonsei university college of medicine|seoul|seoul|south korea` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT01836081*  
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