---
title: 3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis
nct_id: NCT01854788
overall_status: COMPLETED
phase: NA
sponsor: Hospital Clinic of Barcelona
study_type: INTERVENTIONAL
primary_condition: Bronchiectasis
countries: Spain
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01854788.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01854788"
ct_last_update_post_date: 2013-05-16
last_seen_at: "2026-05-12T07:01:35.014Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# 3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis

**Official Title:** A Comparative Study of Three Airway Clearance Techniques With Different Autonomy Degrees in Non Cystic Fibrosis Bronchiectasis: Randomized Cross-over Trial.

**NCT ID:** [NCT01854788](https://clinicaltrials.gov/study/NCT01854788)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 31
- **Lead Sponsor:** Hospital Clinic of Barcelona
- **Conditions:** Bronchiectasis
- **Start Date:** 2010-09
- **Completion Date:** 2012-08
- **CT.gov Last Update:** 2013-05-16

## Brief Summary

Study design: a randomized, crossover trial. Each patient performed three different airway clearance techniques (Autogenic drainage, slow expiratory with glottis opened in lateral posture \[ELTGOL\], temporary- positive expiratory pressure \[T-PEP\] with not similar autonomy degree in a randomized order. Each technique were applied in 3 sessions during one week at alternate days (Monday /Wednesday/Friday or Tuesday/Thursday/Saturday). The time spent in each bronchial session was 40 minutes. Seven days were the wash-out time period between the different techniques.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

1. \- Non Cystic Fibrosis bronchiectasis diagnosed by High Resolution Computed Tomographic
2. \- Mean sputum production ≥ 15 ml /24h
3. \- Clinical stability in the last 6 weeks
4. \- Not carrying out regular chest physiotherapy
5. \- Forced expiratory volume in 1 second ≥ 30% pred. ; Forced Vital Capacity ≥ 45% pred. and peak expiratory flow \>270 L/s

Exclusion Criteria:

1. \- Smoker or non-smoker form less than 2 years
2. \- Cystic fibrosis
3. \- Active tuberculosis or sarcoidosis
```

## Arms

- **Autogenic drainage** (ACTIVE_COMPARATOR) — All patients performed all interventions in a randomized order. Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes
- **Slow expiration with glottis opened in lateral posture** (ACTIVE_COMPARATOR) — All patients performed all interventions in a randomized order.Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes
- **Temporary-Positive Expiratory Pressure** (ACTIVE_COMPARATOR) — All patients performed all interventions in a randomized order. Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes

## Interventions

- **Autogenic drainage** (OTHER) — It was performed following J. Chevallier recommendations.In this trial it was considered a self-administrated technique because physiotherapist only gave oral advice in order to ensure a correct performance of the technique.
- **Slow expiration with glottis opened in lateral posture** (OTHER) — It was performed following Postiaux´s recommendations. In this trial the technique was considered active-assisted because the physiotherapy played a role important in their execution.
- **Temporary-positive expiratory pressure** (OTHER) — The diaphragmatic breathing was required for this technique whereas patients remain seated in front of the device with a nose clip. The inspiratory /expiratory ratio was 1:2.It was taken into account as a device-administrated technique for this trial.

## Primary Outcomes

- **Weight of sputum expectorated during each airway clearance therapy session** _(time frame: 40 minutes)_ — Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.
- **Weight of sputum expectorated 24 hours post each bronchial session** _(time frame: 24 hours)_ — Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.

## Secondary Outcomes

- **Saint George Respiratory Questionnaire (SGRQ)** _(time frame: Change from baseline at 5 weeks)_
- **Leicester Cough Questionnaire (LCQ)** _(time frame: Changes from baseline arm to 1 week)_

## Locations (1)

- Hospital CLinic, Barcelona, Barcelona, Spain

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.hospital clinic|barcelona|barcelona|spain` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01854788.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01854788*  
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