---
title: Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy
nct_id: NCT01926301
overall_status: WITHDRAWN
sponsor: Johannes Gutenberg University Mainz
study_type: OBSERVATIONAL
primary_condition: Severe Sepsis
countries: Germany
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT01926301.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT01926301"
ct_last_update_post_date: 2020-06-11
last_seen_at: "2026-05-12T06:29:22.213Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

**Official Title:** Cerebrovascular Autoregulation in Patients With Severe Sepsis and Septic Shock, Influence of Renal Replacement Therapy

**NCT ID:** [NCT01926301](https://clinicaltrials.gov/study/NCT01926301)

## Key Facts

- **Status:** WITHDRAWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 0
- **Lead Sponsor:** Johannes Gutenberg University Mainz
- **Conditions:** Severe Sepsis, Septic Shock
- **Start Date:** 2013-08
- **Completion Date:** 2020-06
- **CT.gov Last Update:** 2020-06-11

## Brief Summary

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.

Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* severe sepsis or septic shock
* adult patients
* possibility of transcranial Doppler ultrasound

Exclusion Criteria:

* traumatic brain injury
* known cerebrovascular diseases
* Infection of the brain
* chronic renal failure
* pregnancy
```

## Arms

- **Hemodialysis** — Patients with severe sepsis or septic shock with acute renal failure and requirement of continuous veno-venous hemodialysis
- **No hemodialysis** — Patients with severe sepsis or septic shock without acute renal failure and no requirement of continuous veno-venous hemodialysis

## Interventions

- **continuous veno-venous hemodialysis** (PROCEDURE)

## Primary Outcomes

- **Cerebrovascular autoregulation** _(time frame: during the first 4 days)_ — Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock

## Secondary Outcomes

- **Delirium** _(time frame: at day 4)_

## Locations (1)

- University Medical Center of the Johannes Gutenberg-Univerity, Mainz, Germany

## Recent Field Changes (last 30 days)

- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `locations.university medical center of the johannes gutenberg-univerity|mainz||germany` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT01926301.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT01926301*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*