---
title: Study of Betatrophin Levels in Patients With Type 2 Diabetes and Gestational Diabetes and Healthy Subjects
nct_id: NCT02025673
overall_status: UNKNOWN
sponsor: Qingdao University
study_type: OBSERVATIONAL
primary_condition: Pregnancy
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02025673.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02025673"
ct_last_update_post_date: 2014-01-01
last_seen_at: "2026-05-12T06:19:22.513Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Study of Betatrophin Levels in Patients With Type 2 Diabetes and Gestational Diabetes and Healthy Subjects

**NCT ID:** [NCT02025673](https://clinicaltrials.gov/study/NCT02025673)

## Key Facts

- **Status:** UNKNOWN
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 200
- **Lead Sponsor:** Qingdao University
- **Conditions:** Pregnancy, Gestational Diabetes Mellitus (GDM), Type 2 Diabetes
- **Start Date:** 2013-08
- **Completion Date:** 2014-07
- **CT.gov Last Update:** 2014-01-01

## Brief Summary

Betatrophin is a newly identified hormone that promotes pancreatic beta cell proliferation, improves glucose tolerance and regulates lipids metabolism. A recent study showed that circulating concentrations of betatrophin doubled in type 1 diabetes. The objective of this study is to investigate the association of serum betatrophin levels with the progression of diabetic retinopathy in patients with type 2 diabetes and the level of betatrophin in gestational diabetes patients and pregnant women.

## Detailed Description

200 subjects were recruited in this study and divided into six groups for comparison of the serum betatrophin. 70 healthy subjects and 20 healthy young volunteers were enrolled for investigating the role of betatrophin in energy homeostasis and the circadian rhythm. 50 patients with type 2 diabetes were classified into three groups by the stage of diabetic retinopathy. Rank test was used to analyze the correlation between the progression of diabetic retinopathy and circulating betatrophin. Betatrophin were measured by a commercially available enzyme-linked immunosorbent assay and confirmed via Western Blot.

## Eligibility

- **Minimum age:** 20 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Type 2 diabetes mellitus patients
* Patients with HbA1c \>or= 7.0%

Exclusion Criteria:

* Participation in other investigational Clinical Trial
* Type 1 diabetes mellitus patients
* Patients with history of severe hepatic dysfunction
* Treatment with antifungal agent especially Miconazole
* Patients with active smoking or history of smoking cessation less than 2 months
```

## Arms

- **Healthy Controls** — Healthy subjects as control group.
- **Type 2 diabetes** — Patients with type 2 diabetes.
- **Gestational diabetes mellitus** — Patients with gestational diabetes mellitus.

## Primary Outcomes

- **Serum levels of betatrophin in type 2 diabetes patients, gestational diabetes patients and pregnant women** _(time frame: Up to one month)_

## Secondary Outcomes

- **Correlation of betatrophin concentration with other variables** _(time frame: Up to one month)_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02025673.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02025673*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*