---
title: Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat
nct_id: NCT02252419
overall_status: UNKNOWN
phase: NA
sponsor: Seoul National University Hospital
study_type: INTERVENTIONAL
primary_condition: Pharyngitis
countries: South Korea
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02252419.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02252419"
ct_last_update_post_date: 2014-10-17
last_seen_at: "2026-05-12T06:30:36.685Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

**Official Title:** Combined Effect of Preoperative Dexamethasone and Intraoperative Paracetamol on Postoperative Sore Throat for Patients Undergoing Urologic Surgery

**NCT ID:** [NCT02252419](https://clinicaltrials.gov/study/NCT02252419)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 242
- **Lead Sponsor:** Seoul National University Hospital
- **Conditions:** Pharyngitis
- **Start Date:** 2014-10
- **Completion Date:** 2015-03
- **CT.gov Last Update:** 2014-10-17

## Brief Summary

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

## Detailed Description

The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated.

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

## Eligibility

- **Minimum age:** 19 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients scheduled for urologic surgery under general anesthesia
* ASA I-III

Exclusion Criteria:

* Patients with recent sore throat
* Patients with neck surgery
* Patients with anticipated difficult airway
* Patients with Mallampati grade 3
* Patients with severe cardiovascular or pulmonary disease
* Patients with allergic history to dexamethasone or paracetamol
* Patients with liver function disorder
* Patients with liver disease
```

## Arms

- **Dexamethasone** (ACTIVE_COMPARATOR) — Dexamethasone will be administered 30 minutes before the anesthetic induction.
- **Dexamethasone+ Paracetamol (DP)** (EXPERIMENTAL) — Dexamethasone will be administered 30 minutes before the anesthetic induction. Paracetamol will be administered at the end of the surgery.

## Interventions

- **Dexamethasone** (DRUG) — Dexamethasone will be administered.
- **Paracetamol** (DRUG) — Paracetamol will be administered.

## Primary Outcomes

- **Postoperative sore throat** _(time frame: 1 hour postoperatively)_ — Postoperative sore throat after 1 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe)

## Secondary Outcomes

- **Postoperative sore throat degree** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Postoperative pain** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Nausea** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Vomiting** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Somnolence** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Shivering** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Headache** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Hoarseness** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Dysphagia** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Analgesics** _(time frame: 0, 1, 6, 24 hour postoperatively)_
- **Postoperative sore throat** _(time frame: 0, 6, 24 hour postoperatively)_

## Locations (1)

- Seolu National University of Hospital, Seoul, South Korea

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.seolu national university of hospital|seoul||south korea` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02252419.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02252419*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*