---
title: NMES During the Day and Prior to Sleep
nct_id: NCT02253329
overall_status: COMPLETED
phase: NA
sponsor: Maastricht University Medical Center
study_type: INTERVENTIONAL
primary_condition: Sarcopenia
countries: Netherlands
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02253329.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02253329"
ct_last_update_post_date: 2015-05-21
last_seen_at: "2026-05-12T06:24:33.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# NMES During the Day and Prior to Sleep

**Official Title:** The Effect of Neuromuscular Electrical Stimulation on Post-prandial Protein Accretion During the Day and Prior to Sleep

**NCT ID:** [NCT02253329](https://clinicaltrials.gov/study/NCT02253329)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 16
- **Lead Sponsor:** Maastricht University Medical Center
- **Conditions:** Sarcopenia
- **Start Date:** 2015-01
- **Completion Date:** 2015-05
- **CT.gov Last Update:** 2015-05-21

## Brief Summary

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

## Detailed Description

In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

## Eligibility

- **Minimum age:** 65 Years
- **Maximum age:** 85 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Age 65-85 years
* Male
* 18.5 ≤ BMI ≤ 30.0

Exclusion Criteria:

* Type II diabetes
* All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
* Use of anticoagulants, blood diseases, allergy for lidocaine
* Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid
* Patients suffering from PKU (Phenylketonuria)
* Presence of implantable cardioverter defibrillator and/or pacemaker
* Performed regular resistance type exercise in the past 6 months
* Use of any tools to assist during walking (cane/ crutches/ walker)
* (Partial) foot/ leg amputation
```

## Arms

- **Treatment during the day** (ACTIVE_COMPARATOR) — Neuromuscular electrical stimulation after a protein bolus, performed during the day
- **Treatment prior to sleep** (ACTIVE_COMPARATOR) — Protein ingestion directly after one-legged NMES, directly prior to sleep

## Interventions

- **Dietary protein plus NMES during the day** (PROCEDURE) — Neuromuscular electrical stimulation after a protein bolus, performed during the day
- **Dietary protein plus NMES prior to sleep** (PROCEDURE) — Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep

## Primary Outcomes

- **Incorporation of stable isotope amino acids into skeletal muscle tissue** _(time frame: 4-8 hours in the postprandial phase)_

## Secondary Outcomes

- **Plasma amino acid enrichment** _(time frame: 4-8 hours in the postprandial phase)_

## Locations (1)

- Maastricht University Medical Centre +, Maastricht, Netherlands

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.maastricht university medical centre +|maastricht||netherlands` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02253329.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02253329*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*