---
title: Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients
nct_id: NCT02387541
overall_status: COMPLETED
sponsor: General Hospital of Ningxia Medical University
study_type: OBSERVATIONAL
primary_condition: Perioperative Complications
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02387541.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02387541"
ct_last_update_post_date: 2016-05-03
last_seen_at: "2026-05-12T06:20:53.385Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effects of Total Knee Replacement on Early Postoperative Cognitive Function in Elderly Patients

**NCT ID:** [NCT02387541](https://clinicaltrials.gov/study/NCT02387541)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 100
- **Lead Sponsor:** General Hospital of Ningxia Medical University
- **Conditions:** Perioperative Complications
- **Start Date:** 2012-03
- **Completion Date:** 2014-01
- **CT.gov Last Update:** 2016-05-03

## Brief Summary

To investigate the effects of total knee replacement is harmful to Postoperative cognitive dysfunction

## Detailed Description

Postoperative cognitive dysfunction (POCD) is reported to occur after major surgery in elderly patients. They may especially experience problems in the weeks and months after surgery. Recent studies vary greatly in methods of evaluation and diagnosis of POCD, and the pathogenic mechanisms are still unclear. The investigators evaluated a large uniform cohort of elderly patients in a standardized approach after total knee replacement.

## Eligibility

- **Minimum age:** 65 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* aged ≥65 years;
* ASA I or Ⅱ;
* total knee replacement

Exclusion Criteria:

* Mini Mental State Examination \[MMSE\] score too low.
* Parkinson or other neurological disease causing functional impairment.
* Patients with a history of alcohol abuse (≥35 U per week) or daily use of anxiolytics were also excluded, as well as those with severe hearing or visual impairment.
```

## Primary Outcomes

- **Effects of operation on early postoperative cognitive function in elderly patients** _(time frame: up to 7days postoperatively)_

## Secondary Outcomes

- **Postoperative cognitive dysfunction (POCD) was defined by Mini-Mental State Examination (MMSE) score** _(time frame: up to 7days postoperatively)_

## Recent Field Changes (last 30 days)

- `design.enrollmentCount` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02387541.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02387541*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*