---
title: Ischaemic PReconditioning In Non Cardiac surgEry
nct_id: NCT02427867
overall_status: ACTIVE_NOT_RECRUITING
phase: NA
sponsor: Università Vita-Salute San Raffaele
study_type: INTERVENTIONAL
primary_condition: Myocardial Ischemia
countries: China, Colombia, Croatia, Italy, Kazakhstan, Russia, Serbia, Singapore, Switzerland
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02427867.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02427867"
ct_last_update_post_date: 2026-05-11
last_seen_at: "2026-05-12T07:19:01.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Ischaemic PReconditioning In Non Cardiac surgEry

**NCT ID:** [NCT02427867](https://clinicaltrials.gov/study/NCT02427867)

## Key Facts

- **Status:** ACTIVE_NOT_RECRUITING
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 1217
- **Lead Sponsor:** Università Vita-Salute San Raffaele
- **Conditions:** Myocardial Ischemia, Surgery
- **Start Date:** 2015-04
- **Completion Date:** 2026-12
- **CT.gov Last Update:** 2026-05-11

## Brief Summary

Several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery.

Remote ischemic preconditioning by brief episodes of ischemia and reperfusion in a remote organ or vascular territory provides protection from injury by myocardial ischemia and reperfusion. In the translation of remote ischemic preconditioning from bench to bedside, the first proof of principle and small randomized controlled trials have shown a decreased release of myocardial biomarkers after aortic, congenital cardiac, adult valve and coronary artery by-pass graft surgery. This reduction in cardiac biomarkers release translated into better survival in a recent randomized trial performed in cardiac surgery. No clinical trial on remote ischemic preconditioning in non-cardiac surgery setting has been performed so far.

The investigators study wants to test, for the first time, the hypothesis that remote ischaemic preconditioning is effective in reducing cardiac damage in high risk patients undergoing non-cardiac surgery. Remote ischaemic preconditioning will be achieved by inflation of a blood-pressure cuff to 200 mm Hg to the upper arm for 5 minutes, followed by 5 minutes reperfusion while the cuff will be deflated. General anesthesia will be induced and maintained without using propofol in both groups. Cardiac troponin will be used as marker of cardiac damage. If the results of a reduction in postoperative cardiac troponin release and perioperative cardiac ischaemic events will be confirmed in a non-cardiac surgery setting, the investigators could improve a strategy to prevent perioperative cardiac complication easy to apply, safe and low cost.

## Eligibility

- **Minimum age:** 50 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* written informed consent
* intermedial and high risk non cardiac surgery
* general anesthesia
* ongoing or recently suspended antiplatelet therapy

Exclusion Criteria:

* pregnancy
* planned locoregional anesthesia without general anesthesia
* unstable or ongoing angina
* recent (\< 1 month) or ongoing acute myocardial infarction
* inclusion in other randomised controlled studies in the previous 30 days
* peripheral vascular disease affecting the upper limbs
* cardiac surgery
```

## Arms

- **remote ischemic preconditioning** (EXPERIMENTAL) — Three cycles of 5 minutes ischemia will be applied to the upper left arm (or right arm or legs if the left arm will not be deemed suitable by the attending physician), achieved by inflation of a blood-pressure cuff to 200 mm Hg, followed by 5 minutes reperfusion while the cuff will be deflated.
- **no ischemic preconditioning** (PLACEBO_COMPARATOR) — The cuff will be placed around the arm but not inflated.

## Interventions

- **Remote ischemic preconditioning** (OTHER)
- **no ischemic preconditioning** (OTHER)

## Primary Outcomes

- **cardiac troponin** _(time frame: Hospital - approximately 1 week)_ — elevation of cardiac troponin after non-cardiac surgery

## Locations (26)

- Xijing Hospital, Xi'an, China
- Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia
- University Hospital Centre Zagreb, Zagreb, Croatia
- Humanitas Clinical Institute, Rozzano, Lombardy, Italy
- Valle Olona Po hospital, Busto Arsizio, Varese, Italy
- Ospedale Cardinal Massaia, Asti, Italy
- Azienda Ospedaliero Universitaria Careggi, Florence, Italy
- E.O. Ospedali Galliera, Genova, Italy
- IRCCS San Raffaele Scientific Institute, Milan, Italy
- Fondazione IRCCS. Istituto Neurologico Carlo Besta, Milan, Italy
- Università degli studi della Campania Luigi Vanvitelli, Naples, Italy
- Azienda Universitaria Ospedaliero Pisana, Pisa, Italy
- A.O.U. Pisana, Pisa, Italy
- Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- ULSS 4 Veneto Orientale, Ospedale di San Donà di Piave, San Donà di Piave, Italy
- Azienda Sanitaria Universitaria Friuli Centrale "Santa Maria della Misericordia", Udine, Italy
- Astana Medical University, Astana, Kazakhstan
- Loginov Moscow Clinical Scientific Center, Moscow, Russia
- Oncological Center No. 1 of the S. S. Yudin City Clinical Hospital of the Moscow Department of Health, Moscow, Russia
- I.M. Sechenov First Moscow State Medical, Moscow, Russia
- V.Negovsky Reanimatolgy Research Institute, Moscow, Russia
- Saint-Petersburg State University Hospital, Saint Petersburg, Russia
- Institute of Cardiovascular Diseases "Dedinje", Belgrade, Serbia
- National University Hospital, Singapore, Singapore
- Ospedale Regionale di Lugano, Lugano, Switzerland

## Recent Field Changes (last 30 days)

- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `locations.e.o. ospedali galliera|genova||italy` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.xijing hospital|xi'an||china` — added _(2026-05-12)_
- `locations.fundación cardioinfantil-instituto de cardiología|bogotá||colombia` — added _(2026-05-12)_
- `locations.university hospital centre zagreb|zagreb||croatia` — added _(2026-05-12)_
- `locations.humanitas clinical institute|rozzano|lombardy|italy` — added _(2026-05-12)_
- `locations.valle olona po hospital|busto arsizio|varese|italy` — added _(2026-05-12)_
- `locations.ospedale cardinal massaia|asti||italy` — added _(2026-05-12)_
- `locations.azienda ospedaliero universitaria careggi|florence||italy` — added _(2026-05-12)_
- `locations.irccs san raffaele scientific institute|milan||italy` — added _(2026-05-12)_
- `locations.fondazione irccs. istituto neurologico carlo besta|milan||italy` — added _(2026-05-12)_
- `locations.università degli studi della campania luigi vanvitelli|naples||italy` — added _(2026-05-12)_
- `locations.azienda universitaria ospedaliero pisana|pisa||italy` — added _(2026-05-12)_
- `locations.a.o.u. pisana|pisa||italy` — added _(2026-05-12)_
- `locations.fondazione policlinico universitario campus bio-medico di roma|rome||italy` — added _(2026-05-12)_
- `locations.fondazione policlinico universitario agostino gemelli irccs|rome||italy` — added _(2026-05-12)_
- `locations.ulss 4 veneto orientale, ospedale di san donà di piave|san donà di piave||italy` — added _(2026-05-12)_
- `locations.azienda sanitaria universitaria friuli centrale "santa maria della misericordia"|udine||italy` — added _(2026-05-12)_
- `locations.astana medical university|astana||kazakhstan` — added _(2026-05-12)_
- `locations.loginov moscow clinical scientific center|moscow||russia` — added _(2026-05-12)_
- `locations.oncological center no. 1 of the s. s. yudin city clinical hospital of the moscow department of health|moscow||russia` — added _(2026-05-12)_
- `locations.i.m. sechenov first moscow state medical|moscow||russia` — added _(2026-05-12)_
- `locations.v.negovsky reanimatolgy research institute|moscow||russia` — added _(2026-05-12)_
- `locations.saint-petersburg state university hospital|saint petersburg||russia` — added _(2026-05-12)_
- `locations.institute of cardiovascular diseases "dedinje"|belgrade||serbia` — added _(2026-05-12)_
- `locations.national university hospital|singapore||singapore` — added _(2026-05-12)_
- `locations.ospedale regionale di lugano|lugano||switzerland` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02427867.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02427867*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*