---
title: Ridge Preservation Comparing the Clinical and Histologic Healing of Flap vs. Flapless Approach to Grafting
nct_id: NCT02487758
overall_status: COMPLETED
phase: NA
sponsor: University of Louisville
study_type: INTERVENTIONAL
primary_condition: Jaw, Edentulous, Partially
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02487758.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02487758"
ct_last_update_post_date: 2016-12-08
last_seen_at: "2026-05-12T06:44:14.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Ridge Preservation Comparing the Clinical and Histologic Healing of Flap vs. Flapless Approach to Grafting

**NCT ID:** [NCT02487758](https://clinicaltrials.gov/study/NCT02487758)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 24
- **Lead Sponsor:** University of Louisville
- **Conditions:** Jaw, Edentulous, Partially
- **Start Date:** 2015-08
- **Completion Date:** 2016-05
- **CT.gov Last Update:** 2016-12-08

## Brief Summary

Ridge Preservation Comparing the Clinical and Histologic Healing of Flap vs. Flapless Approach to Grafting

## Detailed Description

Thirty patients will be treated using the principles of guided bone regeneration and ridge preservation. Fifteen test patients will receive the flapless technique with an intrasocket cancellous cortical particulate allograft plus a facial overlay graft using a bovine xenograft plus Alloderm GBR. The positive control group of fifteen patients will receive the flap technique with an intrasocket cancellous cortical particulate allograft plus a facial overlay graft using a bovine xenograft plus Alloderm GBR. Approximately, four months post-surgery, a trephine core will be taken from the grafted site immediately prior to implant placement and submitted for histologic processing.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

1. Have one non-molar tooth requiring extraction that will be replaced by a dental implant. The site must be bordered by at least one tooth.
2. Healthy male or female who is at least 18 years old.
3. Patients must sign an informed consent approved by the University of Louisville Human Studies Committee.

Exclusion Criteria:

1. Patients with debilitating systemic diseases, or diseases that have a clinically significant effect on the periodontium.
2. Presence or history of osteonecrosis of jaws.
3. Patients who are currently taking IV bisphosphonates or who had IV treatment with bisphosphonates irrespective of duration.
4. Patients who have been treated with oral bisphosphonates for more than three years.
5. Patients with an allergy to any material or medication used in the study.
6. Previous head and neck radiation therapy.
7. Chemotherapy in the previous 12 months.
8. Pregnant patients.
```

## Arms

- **Ridge preservation Flap** (EXPERIMENTAL) — The flap procedure will consist of a full-thickness papilla preservation flap performed on the buccal and a full thickness flap on the palatal.
- **Ridge preservation Flapless** (EXPERIMENTAL) — The test will be a flapless technique with tunneling and an intramucosal vertical incision on the buccal.

## Interventions

- **Ridge Preservation** (PROCEDURE) — Ridge Preservation Comparing the Clinical and Histologic Healing of Flap vs. Flapless Approach to Grafting

## Primary Outcomes

- **Change in post-extraction site to 4 month change in crestal osseous width** _(time frame: 4 months)_ — Changes in post-extraction to 4 month change in ridge measurements at the mid-defect alveolar crest and 5 mm apical taken with a caliper.

## Secondary Outcomes

- **Change in Soft tissue thickness** _(time frame: 4 months)_
- **Percent osseous tissue** _(time frame: 4 months)_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02487758.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02487758*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*