---
title: Myocardial Flow Reserve in Severe AS Without Obstructive Coronary Artery Disease
nct_id: NCT02575768
overall_status: COMPLETED
sponsor: Samsung Medical Center
study_type: OBSERVATIONAL
primary_condition: Chest Pain
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02575768.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02575768"
ct_last_update_post_date: 2015-10-15
last_seen_at: "2026-05-12T06:51:32.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Myocardial Flow Reserve in Severe AS Without Obstructive Coronary Artery Disease

**Official Title:** Reduced Myocardial Flow Reserve in Exertional Angina With Severe Aortic Stenosis and Normal Coronary Arteries: Insight From Prospective Observational Adenosine-stress Cardiac Magnetic Resonance Imaging Study

**NCT ID:** [NCT02575768](https://clinicaltrials.gov/study/NCT02575768)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 104
- **Lead Sponsor:** Samsung Medical Center
- **Conditions:** Chest Pain, Severe Aortic Stenosis
- **Start Date:** 2012-06
- **Completion Date:** 2015-04
- **CT.gov Last Update:** 2015-10-15

## Brief Summary

Exertional angina is common symptom in patients with severe aortic stenosis (AS) without obstructive coronary artery disease (CAD). Although reduced myocardial flow reserve is one of the proposed explanations for angina, little is known about the pathophysiology.

This study aimed that adenosine-stress cardiac magnetic resonance can be used for the assessment of myocardial perfusion reserve and suggest the pathophysiology of development of angina in patients with severe AS without obstructive CAD.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

1. severe AS
2. normal LV ejection fraction (EF ≥ 50%)

Exclusion Criteria:

1. age \<18
2. LVEF \< 50% in echocardiography
3. concomitant other valvular disease of moderate or severe severity
4. previous aortic valve replacement
5. symptomatic patients other than chest pain
6. obstructive CAD (\>30% luminal stenosis in at least one coronary artery on coronary angiography)
7. history of myocardial infarction or acute coronary syndrome
8. contraindication to adenosine
9. any absolute contraindication to CMR
10. estimated glomerular filtration rate \<30 mL/min/1.73m2.
```

## Arms

- **Severe AS: asymptomatic** — Asymptomatic
- **Severe AS: pure angina** — Presence of exertional chest pain
- **Normal controls** — Healthy controls

## Interventions

- **Adenosine-stress cardiac magnetic resonance imaging** (OTHER) — undergoing adenosine-stress cardiac magnetic resonance imaging

## Primary Outcomes

- **Values of the myocardial perfusion reserve index (MPRI)** _(time frame: Day 1)_ — Signal intensity-time curves were generated for all segments and the maximum upslope of the LV myocardium divided by the maximum upslope of the LV cavity. MPRI \[upslopestress(corrected)/upsloperest(corrected)\] was calculated dividing the segmental upslope value during adenosine and rest. Whole (average of all myocardial segments) MPRI were calculated.

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02575768.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02575768*  
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