---
title: Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation
nct_id: NCT02772939
overall_status: COMPLETED
phase: NA
sponsor: Heart Center Leipzig - University Hospital
study_type: INTERVENTIONAL
primary_condition: Therapy Resistant Arterial Hypertension
countries: Germany
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT02772939.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT02772939"
ct_last_update_post_date: 2022-08-10
last_seen_at: "2026-05-12T07:13:54.485Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation

**Official Title:** Evaluation of Arterial Stiffness as a Predictor of Response to Renal Sympathetic Denervation

**NCT ID:** [NCT02772939](https://clinicaltrials.gov/study/NCT02772939)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 80
- **Lead Sponsor:** Heart Center Leipzig - University Hospital
- **Conditions:** Therapy Resistant Arterial Hypertension
- **Start Date:** 2015-06
- **Completion Date:** 2022-05
- **CT.gov Last Update:** 2022-08-10

## Brief Summary

This trial is designed to establish invasive and non-invasive measures of arterial stiffness as potential predictors of treatment response to renal sympathetic denervation

## Detailed Description

Regardless of the ongoing debate on the general effect of renal sympathetic denervation in therapy resistant hypertension, all trials published so far face the problem of a certain proportion of nonresponders to treatment. Previous data shows, that to some extent this might be attributable to arterial stiffening. Elevated invasive pulse wave velocity as an established marker for arterial stiffness has been found to be associated with nonresponse to renal denervation treatment in a smaller trial population. This trial attempts to assess the predictive value of different invasive and non-invasive markers for arterial stiffness in an adequately powered population.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients with therapy resistant arterial hypertension (\>=3 antihypertensive drugs including at least one diuretic without any dosage change in the preceding 4 weeks) and office BP \>160 mmHg systolic or 90 mmHg diastolic

Exclusion Criteria:

* average systolic daytime BP \<135 mmHg in 24h ambulatory blood pressure measurement (ABPM)
* pregnancy
* known renal artery stenosis
* \>= 1 renal artery diameter \< 4 mm
* life expectancy \<6 months
* participation in any other clinical trial
```

## Arms

- **Renal Denervation** (EXPERIMENTAL) — Renal denervation for therapy resistant arterial hypertension

## Interventions

- **Renal sympathetic denervation (RDN)** (DEVICE) — Catheter based renal sympathetic denervation for therapy resistant arterial hypertension

## Primary Outcomes

- **Predictive value of invasive Pulse wave velocity for blood pressure response after renal denervation** _(time frame: 3 Months)_ — difference in daytime blood pressure (ABPM) between patients with low (\<14.4 m/s) vs. high invasive pulse wave velocity
- **Predictive value of noninvasive and invasive measures of arterial stiffness (Pulse wave velocity assessed invasively, with a piezoelectric device and MRI-based) in combination with clinical variables** _(time frame: 3 Months)_ — AUC of ROCs for noninvasive and invasive measures of arterial stiffness in predicting blood pressure response to renal denervation

## Secondary Outcomes

- **Change in 24h ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_
- **Change in exercise blood pressure** _(time frame: 3 months)_
- **Predictive value of MRI-assessed aortic distensibility on Change in daytime ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_
- **Predictive value of MRI-assessed aortic distensibility on Change in 24 h ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_
- **Predictive value of MRI-assessed total arterial compliance on Change in daytime ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_
- **Predictive value of MRI-assessed total arterial compliance on Change in 24 h ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_
- **comparison of predictive value of invasive pulse wave velocity, invasive central pulse pressure, noninvasive pulse wave velocity, noninvasive central pulse pressure, aortic distensibility, total arterial compliance for Change in ambulatory blood pressure** _(time frame: 3 months, 6 months, 12 months)_

## Locations (1)

- Heart Center of the University Leipzig, Leipzig, Germany

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.heart center of the university leipzig|leipzig||germany` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT02772939.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT02772939*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*