---
title: MOSE to Improve the Diagnostic Accuracy During EUS-guided FNA Using a 19-gauge Needle for Solid Lesions
nct_id: NCT03130140
overall_status: COMPLETED
phase: NA
sponsor: Chinese University of Hong Kong
study_type: INTERVENTIONAL
primary_condition: Solid Tumor
countries: Hong Kong
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03130140.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03130140"
ct_last_update_post_date: 2018-12-06
last_seen_at: "2026-05-12T06:50:23.713Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# MOSE to Improve the Diagnostic Accuracy During EUS-guided FNA Using a 19-gauge Needle for Solid Lesions

**Official Title:** Macroscopic On-site Quality Evaluation of Biopsy Specimens to Improve the Diagnostic Accuracy During EUS-guided FNA Using a 19-gauge Needle for Solid Lesions: a Multicenter Prospective Randomized Controlled Study

**NCT ID:** [NCT03130140](https://clinicaltrials.gov/study/NCT03130140)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 244
- **Lead Sponsor:** Chinese University of Hong Kong
- **Conditions:** Solid Tumor
- **Start Date:** 2016-02-26
- **Completion Date:** 2018-09-01
- **CT.gov Last Update:** 2018-12-06

## Brief Summary

The technique of macroscopic on-site evaluation (MOSE) has recently been advocated for estimating the adequacy of a core specimen for histological diagnosis during EUS-FNA using a 19-gauge needle. How it compares to the conventional technique of tissue acquisition during EUS-FNA is uncertain.

The objective of this study is to evaluate the quantity and quality of tissue, and the diagnostic ability of MOSE when compared with the conventional combined histologic-cytologic analysis.

## Detailed Description

To evaluate the quantity and quality of tissue, and the diagnostic ability of MOSE when compared with the conventional combined histologic-cytologic analysis in a randomized controlled study.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Consecutive patients (aged between 18 and 80 years) referred for EUS-guided tissue acquisition for intestinal or extra-intestinal solid lesions more than 2cm in the largest diameter would be included.

Exclusion Criteria:

* Patients with coagulopathy, altered anatomy, contraindications for conscious sedation, pregnancy and those who cannot provide informed consent would be excluded.
```

## Arms

- **Macroscopic on-site evaluation** (ACTIVE_COMPARATOR) — EUS-FNA perform with a 19-gauge needle with macroscopic on-site evaluation.
- **Control** (SHAM_COMPARATOR) — EUS-FNA perform with a 19-gauge needle with conventional techniques.

## Interventions

- **Macroscopic on-site evaluation** (PROCEDURE) — Macroscopic on-site evaluation: any aspirated material on a glass slide for inspection of the presence of a macroscopic visible core (MVC). Length of MVC will be measured to determine the adequacy of that puncture.
- **Control** (OTHER) — Conventional EUS-FNA

## Primary Outcomes

- **Diagnostic yield: Proportion of patients with adequate tissue for diagnosis obtained by EUS FNA** _(time frame: 4 weeks)_ — proportion of patients with adequate tissue for diagnosis obtained by EUS FNA

## Locations (1)

- Chinese University of Hong Kong, Hong Kong, Hong Kong

## Recent Field Changes (last 30 days)

- `armsInterventions.arms` — added _(2026-05-12)_
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- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.chinese university of hong kong|hong kong||hong kong` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03130140.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03130140*  
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