---
title: Dextrose Containing Fluid and the Postoperative Nausea and Vomiting in the Gynecologic Laparoscopic Surgery
nct_id: NCT03139383
overall_status: COMPLETED
phase: NA
sponsor: Chiang Mai University
study_type: INTERVENTIONAL
primary_condition: Postoperative Nausea and Vomiting
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03139383.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03139383"
ct_last_update_post_date: 2017-05-08
last_seen_at: "2026-05-12T06:20:12.885Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Dextrose Containing Fluid and the Postoperative Nausea and Vomiting in the Gynecologic Laparoscopic Surgery

**Official Title:** Intraoperative Intravenous Dextrose Administration and the Incidence of Nausea and Vomiting After the Gynecologic Laparoscopic Surgery A Randomized Double-Blinded Controlled Study

**NCT ID:** [NCT03139383](https://clinicaltrials.gov/study/NCT03139383)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 100
- **Lead Sponsor:** Chiang Mai University
- **Conditions:** Postoperative Nausea and Vomiting
- **Start Date:** 2014-09-30
- **Completion Date:** 2015-10-31
- **CT.gov Last Update:** 2017-05-08

## Brief Summary

The investigators tested the hypothesis that administration of intravenous dextrose as a maintenance fluid in gynecologic laparoscopic surgery would reduce the incidence and severity of postoperative nausea and vomiting (PONV) compared with normal saline solution in the same dose.

A prospective randomized double blinded controlled study was conducted. Eighty six participants were randomized to dextrose solution (n= 42) or normal saline solution (n= 44). The Bellville postoperative nausea and vomiting scores were recorded until 24 hours after surgery.

## Detailed Description

Postoperative nausea and vomiting (PONV) is a major complication in laparoscopic gynecologic surgery. There are limited data and conflicting results from previous studies related to the types of intravenous fluid and a reduction in PONV. The incidence of nausea is slightly greater than the incidence of vomiting (50% vs. 30%). General anesthesia increased the likelihood of PONV 11 times compared with other types of anesthesia. Laparoscopic surgery can further increase the incidence of PONV to 80%.Identified risk factors of PONV included female, history of motion sickness, nonsmoking, younger age, general anesthesia, use of volatile anesthetics and nitrous oxide, opioids, duration of anesthesia, and types of surgery (cholecystectomy, laparoscopic, gynecological). Adequate intravenous fluid hydration is another effective strategy for reducing the baseline risk for PONV (Evidence A2). Previous studies showed that there was no difference in efficacy between crystalloids and colloids when similar volumes were used in surgeries associated with minimal fluid shifts. While liberal intravenous fluid administration, such as 30 ml/ kg of sodium lactate solution, reduced the incidence of PONV after gynecologic laparoscopy compared to another group receiving 10 ml/kg of sodium lactate solution, this strategy did not reduce the PONV in other surgical procedures such as thyroidectomy. Among crystalloid solutions, results from previous studies were conflicting regarding the benefit of intravenous dextrose administration to reducing the PONV. Hypovolemia with and without hypoglycemia after overnight fasting were believed to exacerbate PONV.

The investigators hypothesized that intraoperative infusion of dextrose solution could reduce the incidence and severity of PONV. The investigators proposed to determine the relationship between types of fluid administration and antiemetic requirement and serum glucose in paricipants scheduled for the gynecologic laparoscopy.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 65 Years
- **Sex:** FEMALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* ASA I-II
* elective surgery
* Gynecologic laparoscopic surgery
* give informed consent

Exclusion Criteria:

* pregnancy
* DM
* congestive heart failure
```

## Arms

- **normal saline solution** (PLACEBO_COMPARATOR) — The patients received normal saline solution as a maintenance fluid during surgery in dose of 2 ml/kg/hour.
- **dextrose solution** (ACTIVE_COMPARATOR) — The patients received dextrose solution as a maintenance fluid during surgery in dose of 2 ml/kg/hour.

## Interventions

- **dextrose solution** (OTHER) — The patients received 5%D/N/2 during surgery
- **saline solution** (OTHER) — The patients received NSS during surgery

## Primary Outcomes

- **the incidence and severity of postoperative nausea and vomiting** _(time frame: 24 hour after surgery)_ — Bellville score assessment

## Secondary Outcomes

- **Antiemetic drug requirement** _(time frame: 24 hour after surgery)_
- **serum glucose** _(time frame: 2 hour after surgery)_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

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