---
title: Caffeine for Preterm Infants With Apnea of Prematurity(AOP)
nct_id: NCT03298347
overall_status: UNKNOWN
phase: NA
sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
study_type: INTERVENTIONAL
primary_condition: Caffeine
countries: China
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03298347.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03298347"
ct_last_update_post_date: 2017-10-02
last_seen_at: "2026-05-12T06:43:25.484Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Caffeine for Preterm Infants With Apnea of Prematurity(AOP)

**Official Title:** Caffeine for Preterm Infants With Apnea of Prematurity(AOP): a Randomized Controlled Trial

**NCT ID:** [NCT03298347](https://clinicaltrials.gov/study/NCT03298347)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 100
- **Lead Sponsor:** Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- **Conditions:** Caffeine, Apnea of Prematurity
- **Start Date:** 2017-10-01
- **Completion Date:** 2018-10-01
- **CT.gov Last Update:** 2017-10-02

## Brief Summary

Nowadays,caffein is commonly used for AOP, and it reduces the intubation rate in preterm infants. However, intubation is needed in about 20%-50% of partial neonates. How to reduce the intubation rate effectively is a challenge for neonatologists.

## Detailed Description

Less evidences about more dose of caffein used in preterm infants.

## Eligibility

- **Minimum age:** 1 Minute
- **Maximum age:** 1 Month
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* gestational age less than 32 weeks;
* appear AOP;
* parents'consents are obtained.

Exclusion Criteria:

* major congenital abnormalities;
* Parents' rejection
```

## Arms

- **80mg/kg of caffeine** (EXPERIMENTAL) — 80mg/kg of caffeine is given to treat AOP.
- **20mg/kg of caffeine** (ACTIVE_COMPARATOR) — 20mg/kg of caffeine is given to treat AOP.

## Interventions

- **80mg/kg of caffeine** (DRUG) — 80mg/kg of caffeine is given to treat AOP
- **20mg/kg of caffeine** (DRUG) — 20mg/kg of caffeine is given to treat AOP

## Primary Outcomes

- **the rate of AOP** _(time frame: within 100 days)_ — AOP appears again in preterm infants

## Locations (1)

- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Chongqing, Chongqing Municipality, China — _RECRUITING_

## Recent Field Changes (last 30 days)

- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.daping hospital and the research institute of surgery of the third military medical university|chongqing|chongqing municipality|china` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT03298347*  
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