---
title: Macroscopic and Molecular Changes in Knee Muscular - Tendon Unit in Response to Acute Resistant Load
nct_id: NCT03332693
overall_status: UNKNOWN
phase: NA
sponsor: Hillel Yaffe Medical Center
study_type: INTERVENTIONAL
primary_condition: Physical Exertion
countries: Israel
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03332693.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03332693"
ct_last_update_post_date: 2017-11-06
last_seen_at: "2026-05-12T06:38:44.414Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Macroscopic and Molecular Changes in Knee Muscular - Tendon Unit in Response to Acute Resistant Load

**NCT ID:** [NCT03332693](https://clinicaltrials.gov/study/NCT03332693)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 300
- **Lead Sponsor:** Hillel Yaffe Medical Center
- **Conditions:** Physical Exertion
- **Start Date:** 2017-11
- **Completion Date:** 2019-11
- **CT.gov Last Update:** 2017-11-06

## Brief Summary

The aim of this study is to determine whether individuals differ one from the other in their genetic, cellular, systemic, structural and functional response to acute exercise.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 30 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Healthy adults

Exclusion Criteria:

* Unhealthy adults
```

## Arms

- **No exercise** (ACTIVE_COMPARATOR) — Volunteers will not participate in exercise
- **Light exercise** (ACTIVE_COMPARATOR) — Volunteers will participate in one short exercise
- **Heavy exercise** (ACTIVE_COMPARATOR) — Volunteers will participate in heavy exercise

## Interventions

- **Exercise** (OTHER) — Leg weight raising
- **No exercise** (OTHER) — Volunteers will not participate in exercise

## Primary Outcomes

- **Genetic polymorphism changes in knee muscles** _(time frame: One year)_ — Genetic analysis will be made through a blood test and biopsy of knee muscle and results will be compared

## Locations (1)

- Hillel Yaffe Medical Center, Hadera, Israel

## Recent Field Changes (last 30 days)

- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.hillel yaffe medical center|hadera||israel` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03332693.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03332693*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*