---
title: ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients
nct_id: NCT03394131
overall_status: UNKNOWN
phase: NA
sponsor: Assiut University
study_type: INTERVENTIONAL
primary_condition: Treatment Resistant Carpal Tunnel in RA Patients
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03394131.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03394131"
ct_last_update_post_date: 2018-07-13
last_seen_at: "2026-05-12T07:10:41.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

**Official Title:** Treatment of Carpal Tunnel in Rheumatoid Arthritis

**NCT ID:** [NCT03394131](https://clinicaltrials.gov/study/NCT03394131)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 90
- **Lead Sponsor:** Assiut University
- **Conditions:** Treatment Resistant Carpal Tunnel in RA Patients
- **Start Date:** 2017-07-01
- **Completion Date:** 2018-08-01
- **CT.gov Last Update:** 2018-07-13

## Brief Summary

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection using insulin versus hyalase versus saline, ultrasounic guided as an effective treatment

## Detailed Description

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection of median nerve inside CT twice injections with interval 2 weeks using insulin and 10 cc saline versus hyalase and 10 cc saline versus 10 cc saline, ultrasounic guided as an effective treatment of CT

## Eligibility

- **Minimum age:** 20 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Rheumatoid arthritis in remission

Exclusion Criteria:

* active Rheumatoid arthritis
```

## Arms

- **Hyalase** (EXPERIMENTAL) — injection and hydro-dissection of median nerve using hyaluronidase followed by 10 cc normal saline ultrasonic guided
- **Placebo** (PLACEBO_COMPARATOR) — injection and hydro-dissection of median nerve hydro-dissection using 10 cc saline injection ultrasonic guided
- **Insilin** (ACTIVE_COMPARATOR) — injection and hydro-dissection of median nerve hydro-dissection using 10 IU insuline followed by 10 cc normal saline ultrasonic guided

## Interventions

- **Hylase** (DRUG) — hydro-dissection injection of median nerve inside carpal tunnel using hyalase and 10 cc saline
- **Insulin** (DRUG) — hydro-dissection injection of median nerve inside carpal tunnel using 10 IU insulin and 10 cc saline
- **saline** (OTHER) — hydro-dissection injection of median nerve inside carpal tunnel using 10 cc saline

## Primary Outcomes

- **pain intensity** _(time frame: 6 months)_ — Visual analog scale 0-100

## Secondary Outcomes

- **nerve conduction** _(time frame: 6 months)_
- **ultrasound** _(time frame: 6 months)_

## Locations (1)

- Manal Hassanien, Asyut, Assuit, Egypt — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.manal hassanien|asyut|assuit|egypt` — added _(2026-05-12)_

---

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