---
title: Interscalene Block Versus Costoclavicular Block for Shoulder Surgery
nct_id: NCT03411343
overall_status: COMPLETED
phase: NA
sponsor: University of Chile
study_type: INTERVENTIONAL
primary_condition: Pain, Postoperative
countries: Chile
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03411343.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03411343"
ct_last_update_post_date: 2018-07-10
last_seen_at: "2026-05-12T06:46:57.185Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Interscalene Block Versus Costoclavicular Block for Shoulder Surgery

**Official Title:** A Randomized Comparison Between Interscalene and Costoclavicular Infraclavicular Brachial Plexus Blocks For Arthroscopic Shoulder Surgery

**NCT ID:** [NCT03411343](https://clinicaltrials.gov/study/NCT03411343)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 44
- **Lead Sponsor:** University of Chile
- **Conditions:** Pain, Postoperative, Shoulder Pain, Surgical Procedure, Unspecified, Diaphragmatic Paralysis
- **Start Date:** 2018-04-09
- **Completion Date:** 2018-07-06
- **CT.gov Last Update:** 2018-07-10

## Brief Summary

Interscalene brachial plexus block constitutes the analgesic criterion standard for shoulder surgery. However, it is associated with a high incidence of hemidiaphragmatic paralysis (HDP) that may not be tolerated by patients with chronic pulmonary disease. This randomized controlled trial (RCT) will compare ultrasound-guided interscalene block (ISB) and costoclavicular infraclavicular block (CCICB) in patients undergoing arthroscopic shoulder surgery.

The main outcome is static pain at 30 minutes after arrival in the post anesthesia care unit (PACU) as measured by a numerical rate scale (NRS) from 0 to 10. Our research hypothesis is that interscalene and costoclavicular infraclavicular blocks will result in equivalent postoperative analgesia at 30 minutes in the PACU. The equivalence margin is set at 2 points.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients undergoing arthroscopic shoulder surgery
* American Society of Anesthesiologists classification 1-3
* Body mass index between 20 and 35

Exclusion Criteria:

* Adults who are unable to give their own consent
* Pre-existing neuropathy
* Coagulopathy
* Obstructive or restrictive pulmonary disease
* Renal failure
* Hepatic failure
* Allergy to local anesthetics
* Pregnancy
* Prior surgery in the corresponding side of the neck or infraclavicular fossa
* Chronic pain syndromes requiring opioid intake at home
```

## Arms

- **Interscalene Block** (ACTIVE_COMPARATOR) — Patients randomized to receive an intesrcalene block.
- **Costoclavicular Infraclavicular Block** (EXPERIMENTAL) — Patients randomized to receive a costoclavicular infraclavicular block.

## Interventions

- **Interscalene Block** (PROCEDURE) — Injection with ultrasound guidance of 20mL of levobupivacaine 0.5% with 5 micrograms of epinephrine per mL in the interscalene groove of the brachial plexus.
- **Costoclavicular Infraclavicular Block** (PROCEDURE) — Ultrasound guided brachial plexus block injecting 20mL of 0.5% levobupivacaine with 5 micrograms of epinephrine per mL in between the cords of the brachial plexus at the costoclavicular infraclavicular space.

## Primary Outcomes

- **Static pain at 30 minutes after arrival in the PACU** _(time frame: 30 minutes)_ — Evaluated with a NRS from 0 to 10

## Secondary Outcomes

- **Static pain at 60 minutes after arrival in the PACU** _(time frame: 60 minutes)_
- **Postoperative static pain at 2 hours** _(time frame: 2 hours)_
- **Postoperative static pain at 3 hours** _(time frame: 3 hours)_
- **Postoperative static pain at 6 hours** _(time frame: 6 hours)_
- **Postoperative static pain at 12 hours** _(time frame: 12 hours)_
- **Postoperative static pain at 24 hours** _(time frame: 24 hours)_
- **Incidence of HDP at 30 minutes after interscalene or costoclavicular infraclavicular block** _(time frame: 30 minutes post injection)_
- **Incidence of HDP at 30 minutes after arrival to PACU** _(time frame: 30 minutes after arrival to the PACU)_
- **Block performance time** _(time frame: 1 hour before surgery)_
- **Sensory and Motor block score** _(time frame: 30 minutes post injection)_
- **Incidence of complete block** _(time frame: 30 minutes post injection)_
- **Procedural pain during blocks** _(time frame: 1 hour before surgery)_
- **Onset time** _(time frame: 1 hour before surgery)_
- **Intraoperative opioid requirements** _(time frame: Intraoperative period)_
- **Surgical duration** _(time frame: Intraoperative period)_
- **Postoperative opioid consumption** _(time frame: 24 hours after surgery)_
- **Patient satisfaction** _(time frame: 24 hours after surgery)_
- **Block- and opioid-related side effects** _(time frame: 1 week)_

## Locations (1)

- Hospital Clínico Universidad de Chile, Santiago, Santiago Metropolitan, Chile

## Recent Field Changes (last 30 days)

- `eligibility.maxAge` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.hospital clínico universidad de chile|santiago|santiago metropolitan|chile` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03411343.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03411343*  
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