---
title: Improving Learning in Hispanics With TBI or MS
nct_id: NCT03453125
overall_status: UNKNOWN
phase: NA
sponsor: Kessler Foundation
study_type: INTERVENTIONAL
primary_condition: TBI (Traumatic Brain Injury) or MS (Multiple Sclerosis)
countries: United States, Spain
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03453125.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03453125"
ct_last_update_post_date: 2022-01-12
last_seen_at: "2026-05-12T06:01:37.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Improving Learning in Hispanics With TBI or MS

**Official Title:** Improving Learning in Hispanics With TBI or MS: A Pilot Trial

**NCT ID:** [NCT03453125](https://clinicaltrials.gov/study/NCT03453125)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 40
- **Lead Sponsor:** Kessler Foundation
- **Collaborators:** Instituto Vocacional Enrique Díaz de León A.C., Guadalajara, Mexico
- **Conditions:** TBI (Traumatic Brain Injury) or MS (Multiple Sclerosis)
- **Start Date:** 2013-09-25
- **Completion Date:** 2022-09-30
- **CT.gov Last Update:** 2022-01-12

## Brief Summary

The goal of this study is to establish that a memory retraining protocol, originally developed for English-speakers, and translated into Spanish, is effective.

## Detailed Description

A pilot study will be conducted to carry out this validation and resolve any methodological concerns in the translated protocol. 20 Spanish-speaking Hispanics at least one year post-traumatic brain injury (TBI) and 20 Spanish-speaking Hispanics with multiple sclerosis (MS), both with an objective deficit in learning and memory will be recruited. Baseline assessment includes neuropsychological evaluation using traditional measures as well as completion of a number of questionnaires designed to measure everyday memory and everyday functioning. Subjects are randomly assigned to either the experimental or control groups. Experimental and control treatments includes two 45-60 minute sessions, twice per week, for 5 weeks. Follow-up assessment includes a neuropsychological evaluation using traditional measures as well as completion of a number of questionnaires designed to measure everyday memory and everyday functioning. Protocol efficacy will be determined by improvements between baseline and follow-up on an objective measure of learning and memory.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 65 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* between the ages of 18 and 65
* Spanish is my dominant language, and I have had a traumatic brain injury or I have multiple sclerosis.

Exclusion Criteria:

* Participants with major depressive disorder, schizophrenia, bipolar disorder I or II
* MS subjects: Individuals with a history of head injury, stroke, seizures, or any other significant neurological history will not be included in the study.
* TBI subjects: Individuals must have sustained a TBI at least one year prior to enrollment in the study protocol. Individuals with a history of significant neurological insult other than TBI (e.g. premorbid epilepsy, multiple sclerosis, Alzheimer's disease) will not be included in the study.
```

## Arms

- **Spanish mSMT Experimental Treatment** (EXPERIMENTAL) — Administered by computer and paper and pencil.
- **Spanish mSMT Control Treatment** (ACTIVE_COMPARATOR) — Administered by computer and paper and pencil.

## Interventions

- **Spanish modified Story Memory Technique (mSMT)** (BEHAVIORAL)

## Primary Outcomes

- **Total learning post-treatment (covarying for baseline performance)** _(time frame: 7 weeks (between pre- and post testing))_ — Comparison between treatment and control groups on post-treatment Hopkins Verbal Learning Test (HVLT) learning score, covarying for baseline HVLT performance.

## Locations (2)

- Kessler Foundation, East Hanover, New Jersey, United States — _RECRUITING_
- Hospital Aita Menni, Arrasate / Mondragón, Spain — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.kessler foundation|east hanover|new jersey|united states` — added _(2026-05-12)_
- `locations.hospital aita menni|arrasate / mondragón||spain` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03453125.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03453125*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*