---
title: Transpharyngeal Doppler Sonography for Cerebral Perfusion Monitoring
nct_id: NCT03494413
overall_status: COMPLETED
phase: NA
sponsor: Insel Gruppe AG, University Hospital Bern
study_type: INTERVENTIONAL
primary_condition: Cerebral Perfusion
countries: Switzerland
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03494413.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03494413"
ct_last_update_post_date: 2019-05-07
last_seen_at: "2026-05-12T06:54:50.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Transpharyngeal Doppler Sonography for Cerebral Perfusion Monitoring

**Official Title:** Evaluation of Transpharyngeal Doppler Sonography as a Cerebral Monitoring Tool in Cardiac Surgery

**NCT ID:** [NCT03494413](https://clinicaltrials.gov/study/NCT03494413)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 30
- **Lead Sponsor:** Insel Gruppe AG, University Hospital Bern
- **Conditions:** Cerebral Perfusion
- **Start Date:** 2018-07-10
- **Completion Date:** 2019-05-02
- **CT.gov Last Update:** 2019-05-07

## Brief Summary

This prospective interventional study investigates transpharyngeal sonography (TPS) as an additional neuromonitoring strategy to assess cerebral perfusion during cardiovascular surgery. In the first part of the study the investigators will investigate the feasibility of TPS for visualization of aortic arch branches including the innominate and the carotid arteries in patients undergoing cardiac surgery with cardiopulmonary bypass. In the second part the investigators plan to adopt the investigators previous experiences on TPS to a selected population of patients undergoing ascending aortic and/or arch repair in hypothermic circulatory arrest (HCA).

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Cardiovascular Surgery
* Age \> 18 yrs
* Informed Consent

Exclusion Criteria:

* Contraindication for TPS
* Carotid artery stenosis
```

## Arms

- **20 patients (1-20) validation arm** (EXPERIMENTAL) — Accuracy of cerebral flow measurement between TPS and CDS in 20 patients undergoing cardiovascular surgery with cardiopulmonary bypass
- **20 patients (21-40) HCA arm** (EXPERIMENTAL) — Assessment and comparison of TPS and CDS in hypothermic circulatory arrest (HCA) during cardiovascular surgery

## Interventions

- **Transpharyngeal Doppler sonography (TPS)** (DIAGNOSTIC_TEST) — Usage of transpharyngeal Doppler to assess cerebral perfusion during cardiovascular surgery
- **Conventional colour-coded Duplex sonography (CDS)** (DIAGNOSTIC_TEST) — Usage of conventional colour-coded Duplex sonography (CDS) to assess cerebral perfusion during cardiovascular surgery

## Primary Outcomes

- **Accuracy of cerebral flow velocity measurement** _(time frame: intraoperative phase, expected to be ca. 4 hours)_ — Cerebral blood flow velocity measurements will be performed with transpharyngeal Doppler sonography (TPS) and conventional colour-coded Duplex sonography (CDS). Doppler flow velocities (obtained at the same intraoperative phase and at the same time) will be compared between TPS and CDS TPS and different Doppler techniques.

## Secondary Outcomes

- **Hypothermic Circulatory Arrest** _(time frame: intraoperative phase, expected to be ca. 4 hours)_

## Locations (1)

- Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.inselspital, university hospital bern, university of bern|bern||switzerland` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03494413.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03494413*  
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