---
title: "Rehabilitation of Working Memory and Brain Plasticity After Traumatic Brain Injury: Plastim-MDTC"
nct_id: NCT03513133
overall_status: UNKNOWN
phase: NA
sponsor: "Centre d'Investigation Clinique et Technologique 805"
study_type: INTERVENTIONAL
primary_condition: Traumatic Brain Injury
countries: France
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03513133.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03513133"
ct_last_update_post_date: 2018-05-03
last_seen_at: "2026-05-12T07:29:21.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Rehabilitation of Working Memory and Brain Plasticity After Traumatic Brain Injury: Plastim-MDTC

**Official Title:** Rehabilitation of Working Memory After Traumatic Brain Injury: Pilot Study of Brain Plasticity in Multimodal Advanced MRI

**NCT ID:** [NCT03513133](https://clinicaltrials.gov/study/NCT03513133)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 20
- **Lead Sponsor:** Centre d'Investigation Clinique et Technologique 805
- **Conditions:** Traumatic Brain Injury, Cognitive Impairment
- **Start Date:** 2017-07-01
- **Completion Date:** 2019-12-31
- **CT.gov Last Update:** 2018-05-03

## Brief Summary

The aim of this study is to assess the brain correlates, as assessed with multimodal MRI, of working memory training in patients with severe traumatic brain injury (TBI)

## Detailed Description

This is a pilot feasibility study. Patients with subacute/chronic (\> 6 months) severe TBI will be included if they suffer from a deficit in working memory. They will receive a specific hierarchical training of working memory (3 sessions per week during three months), according to a previously described methodology.

A multimodal MRI will be performed at neuroSpin center (CEA, Orsay, France) before and after cognitive training, including: structural imaging (T1, FLAIR and diffusion tensor imaging, DTI); functional connectivity at rest; and functional activation during a working memory task (n-back).

Behavioral and imaging changes after training will be analysed individually and compared to a group of healthy controls matched for age, gender and education.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 55 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* moderate to severe traumatic brain injury
* 6 months or more after the injury
* working memory deficit on cognitive testing

Exclusion Criteria:

* previous neurological or psychiatric condition
* severe behavioral troubles
* contra-indication to MRI
* pregnancy
```

## Arms

- **working memory training** (EXPERIMENTAL) — Patients with severe TBI will receive a hierarchical training of working memory according to a previously described methodology. They will receive 3 sessions per week during three months (each session=1 h approximately)

## Interventions

- **working memory training** (BEHAVIORAL) — Hierarchical cognitive training of the different components of working memory according to Baddeley model; 15 tasks are used addressing: the phonological loop (8 tasks), the visuospatial sketchpad (4 tasks) and the central executive 3 tasks). Task are given in a hierarchical order, according to each individual patient's deficits and improvement.

## Primary Outcomes

- **working memory questionnaire** _(time frame: change from baseline to 3 months)_ — It is a self-assessment questionnaire comprising 30 questions scored on a five-point Likert scale, ranging from 0 ("no problem at all") to 4 ("very severe problem in everyday life"). The total score will be used.

## Secondary Outcomes

- **working memory testing** _(time frame: change from baseline to 3 months)_
- **neuro-imaging changes** _(time frame: change from baseline to 3 months)_

## Locations (1)

- APHP Hôpital Raymond Poincaré, Garches, Île-de-France Region, France — _RECRUITING_

## Recent Field Changes (last 30 days)

- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `locations.aphp hôpital raymond poincaré|garches|île-de-france region|france` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT03513133*  
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