---
title: Effects of Scalp Nerve Block With Ropivacaine on Postoperative Recovery Quality
nct_id: NCT03648034
overall_status: COMPLETED
phase: NA
sponsor: RenJi Hospital
study_type: INTERVENTIONAL
primary_condition: Meningioma
countries: China
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03648034.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03648034"
ct_last_update_post_date: 2020-04-06
last_seen_at: "2026-05-12T06:35:29.213Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effects of Scalp Nerve Block With Ropivacaine on Postoperative Recovery Quality

**Official Title:** Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma

**NCT ID:** [NCT03648034](https://clinicaltrials.gov/study/NCT03648034)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 144
- **Lead Sponsor:** RenJi Hospital
- **Conditions:** Meningioma
- **Start Date:** 2018-09-18
- **Completion Date:** 2019-11-30
- **CT.gov Last Update:** 2020-04-06

## Brief Summary

Patients undergoing elective meningeoma resection surgery will be randomly assigned to one of the following two groups. After anesthesia induction but before skull-pin insertion, one group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline. The patients' postoperative recovery quality, which is evaluated by KPS score, peri-operative inflammatory responses, and post-operative pain degree will be evaluated and compared between the two groups.

## Detailed Description

Patients undergoing elective meningeoma resection surgery will be randomly assigned to one of the following two groups. After anesthesia induction but before skull-pin insertion, one group will receive scalp nerve blocks with 0.5% ropivacaine, whereas the other group will receive scalp nerve blocks with 0.9% saline. The patients' KPS scores at 3d after surgery and at discharge, serum levels of TNF-α、IL-6，IL-1β at 24h after surgery, satisfaction score after recovery, and VAS scores at 1, 2, 3 days post-surgery will be evaluated and compared between the two groups.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

1. 18-75 years old;
2. BMI 18-28 kg/m2;
3. ASA Physical Status 1-2;
4. Clinical diagnosis of primary Meningeoma and will have elective Meningeoma Resection Surgery;
5. With an estimated surgery time of less than 4h;
6. The incision will be conducted at the frontal, top or the temperal skull.

Exclusion Criteria:

1. A history of previous brain surgery;
2. Severe systemic disease (heart, lung, kidney, or immune system);
3. Nerval or mental disorders;
4. A history of addiction to opioids;
5. Allergic to ropivacaine;
6. Infection at block site or severe systemic infection;
7. Refuse to attend the trial.
```

## Arms

- **ropivacaine** (EXPERIMENTAL) — After anesthesia induction but before skull-pin insertion, patients in this group will receive scalp nerve blocks with 0.5% ropivacaine
- **saline** (PLACEBO_COMPARATOR) — After anesthesia induction but before skull-pin insertion, patients in this group will receive scalp nerve blocks with 0.9% saline

## Interventions

- **ropivacaine** (PROCEDURE) — To perform scalp nerve blocks with ropivacaine
- **saline** (PROCEDURE) — To perform scalp nerve blocks with saline

## Primary Outcomes

- **KPS score** _(time frame: 7 days post-surgery)_ — Karnofsky performance score (KPS) allows patients to be classified as to their functional impairment. The total scale range is 0-100. The lower the KPS score, the worse the survival for most serious illnesses.

## Secondary Outcomes

- **KPS score** _(time frame: 3 days post-surgery)_
- **serum TNF-α levels** _(time frame: at 1h and 24h post-surgery)_
- **serum IL-6 levels** _(time frame: at 1h and 24h post-surgery)_
- **serum IL-1β levels** _(time frame: at 1h and 24h post-surgery)_
- **Iowa Satisfaction with Anesthesia Scale (ISAS)** _(time frame: 1 hour after the surgery is finished)_
- **white blood cell** _(time frame: at 24 h after surgery)_
- **serum levels of CRP** _(time frame: at 24 h after surgery)_
- **VAS score** _(time frame: at 1, 2 and 3 days post-surgery)_
- **pain-relief medications** _(time frame: at 1, 2 and 3 days post-surgery)_
- **Hospitalization Days** _(time frame: up to 30 days)_
- **out of pocket expenditure for hospitalisation** _(time frame: hospital discharge/up to 30 days)_
- **complications** _(time frame: within 30 days after surgery)_

## Locations (1)

- Renji Hospital affliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

## Recent Field Changes (last 30 days)

- `locations.renji hospital affliated to shanghai jiaotong university school of medicine|shanghai||china` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

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