---
title: Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol
nct_id: NCT03830970
overall_status: COMPLETED
phase: NA
sponsor: University of Guelph
study_type: INTERVENTIONAL
primary_condition: Hypercholesterolemia
countries: Canada
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03830970.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03830970"
ct_last_update_post_date: 2021-08-05
last_seen_at: "2026-05-12T06:18:57.684Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol

**NCT ID:** [NCT03830970](https://clinicaltrials.gov/study/NCT03830970)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 73
- **Lead Sponsor:** University of Guelph
- **Collaborators:** Canadian Agricultural Partnership Pulse Science Cluster Program, The Bonduelle Company (providing the canned beans)
- **Conditions:** Hypercholesterolemia, Cardiovascular Diseases
- **Start Date:** 2019-03-05
- **Completion Date:** 2021-01-05
- **CT.gov Last Update:** 2021-08-05

## Brief Summary

The Bean Study will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol.

## Detailed Description

The Bean Study (TBS) is a a multi-centre, randomized, crossover design study which will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol. Participants will consume daily amounts of 1 cup canned beans, ½ cup of canned beans and 1 cup of white rice for 4 weeks each, separated by minimum 4-week washout periods. At the start and end of each 4-week treatment period, fasting blood samples will be collected and analyzed for lipids, glucose insulin and short chain fatty acids (SCFAs). Fecal samples will also be collected and analyzed for SCFA, bile acids and gut microbiota. Body weight and BMI will be also be measured at the start and end as well as mid-way of each treatment period. Finally 3-day food records will be completed mid-way during each treatment period.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Male and female adults (≥18 years)
* BMI 18.5-35 kg/m2
* LDL cholesterol 3.0-5.0 mmol/L

Exclusion Criteria:

* Triglycerides ≥3.0 mmol/L
* Diabetes (fasting blood glucose ≥7.0 mmol/L)
* Blood pressure \>140/90 mmHg
* Major medical conditions
* Medical or surgical events requiring hospitalization within the last 3 months
* Medication use that would interfere with the study outcomes (e.g. cholesterol-lowering medications, diabetes-related medications, steroids). All other medications are okay if at a stable (3-month) dose
* Antibiotic use within the last 3 months
* Tobacco product use (\>5 times per week)
* Cannabis use during the study
* Probiotic supplement use (could do a 1-month washout before study)
* Dietary fibre supplement use (could do a 1-month washout before study)
* NHPs used for cholesterol lowering or glycemic control. All other NHPs are okay if at a stable (3-month) dose.
* Pulse consumption \>4 servings per week
* Food allergy or non-food life-threatening allergy
* Pregnant or breastfeeding
* Alcohol consumption (\>14 drinks/week or \>4 drinks/sitting)
* Recent or intended significant weight loss or gain (\>4 kg in previous 3 months)
* National-level or professional athlete
* Overnight shift worker
```

## Arms

- **1 cup of canned beans of multiple varieties** (EXPERIMENTAL) — Consumption of 1 cup of canned beans of multiple varieties each day for 4 weeks
- **1/2 cup of canned beans of multiple varieties** (EXPERIMENTAL) — Consumption of 1/2 cup of canned beans of multiple varieties each day for 4 weeks
- **1 cup of White rice** (OTHER) — Consumption of 1 cup of white rice each day for 4 weeks

## Interventions

- **Canned beans of multiple varieties** (DIETARY_SUPPLEMENT) — Daily rotation of different varieties of canned beans including black, navy, pinto, red kidney and white kidney
- **White Rice** (DIETARY_SUPPLEMENT) — Minute Rice Long Grain White Rice

## Primary Outcomes

- **Fasting serum LDL cholesterol** _(time frame: 4 weeks (28 days))_ — Fasting serum LDL cholesterol will be compared among treatments at study day 29 using ANCOVA and including study day 1 as a covariate

## Secondary Outcomes

- **Fasting serum total cholesterol, HDL cholesterol and triglycerides** _(time frame: 4 weeks (28 days))_
- **Fasting serum glucose and insulin and HOMA-IR** _(time frame: 4 weeks (28 days))_
- **Fasting serum and fecal short chain fatty acids** _(time frame: 4 weeks (28 days))_
- **Fecal bile acids** _(time frame: 4 weeks (28 days))_
- **Gut Microbiota** _(time frame: 4 weeks (28 days))_

## Locations (2)

- Human Nutraceutical Research Unit, Guelph, Ontario, Canada
- Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.human nutraceutical research unit|guelph|ontario|canada` — added _(2026-05-12)_
- `locations.glycemic index laboratories, inc|toronto|ontario|canada` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03830970.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03830970*  
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