---
title: Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children
nct_id: NCT03959605
overall_status: COMPLETED
sponsor: Fondation Ophtalmologique Adolphe de Rothschild
study_type: OBSERVATIONAL
primary_condition: Albinism, Ocular
countries: France
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT03959605.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT03959605"
ct_last_update_post_date: 2021-10-21
last_seen_at: "2026-05-12T06:21:57.585Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children

**NCT ID:** [NCT03959605](https://clinicaltrials.gov/study/NCT03959605)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 48
- **Lead Sponsor:** Fondation Ophtalmologique Adolphe de Rothschild
- **Conditions:** Albinism, Ocular
- **Start Date:** 2019-01-06
- **Completion Date:** 2021-10-01
- **CT.gov Last Update:** 2021-10-21

## Brief Summary

Fovea plana could be the phenoyipic translation of a genetic anomaly in one of the genes identified in albinisme

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* children with albinism
* father and mother of children with albinism

Exclusion Criteria:

* sign of albinism except fovea plana in father or mother of children with albinism
* ophthalmological abnormalities making access to the fundus with OCT impossible
```

## Interventions

- **blood sample for genetic test** (GENETIC) — detection of pathogenic variants among the 19 genes known to be involved in albinism
- **Ophtalmological examination** (DIAGNOSTIC_TEST) — measurement of visual acuity, OCT and OCTA

## Primary Outcomes

- **Number of genetics variants** _(time frame: 1 month)_ — among the genes involved in albinism, identification of those presents in parents of children with albinism

## Locations (1)

- Fondation A de Rothschild, Paris, France

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.fondation a de rothschild|paris||france` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT03959605.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT03959605*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*