---
title: Evaluation of the Hypoalgesic Effects of Transcranial Direct Current (tDCS) in Healthy Subjects
nct_id: NCT04127253
overall_status: UNKNOWN
phase: NA
sponsor: Universidad Autonoma de Madrid
study_type: INTERVENTIONAL
primary_condition: Pain Modulation
countries: Spain
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04127253.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04127253"
ct_last_update_post_date: 2019-10-15
last_seen_at: "2026-05-12T06:25:21.885Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Evaluation of the Hypoalgesic Effects of Transcranial Direct Current (tDCS) in Healthy Subjects

**Official Title:** Evaluation of the Hypoalgesic Effects of Transcranial Direct Current (tDCS) in Combination With Motion Representation Tools in Healthy Subjects: a Double-blind Randomized Placebo-controlled Trial.

**NCT ID:** [NCT04127253](https://clinicaltrials.gov/study/NCT04127253)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 45
- **Lead Sponsor:** Universidad Autonoma de Madrid
- **Collaborators:** Centro Universitario La Salle
- **Conditions:** Pain Modulation
- **Start Date:** 2020-01-01
- **Completion Date:** 2020-07-01
- **CT.gov Last Update:** 2019-10-15

## Brief Summary

The main objective of this research is to evaluate and quantify hypoalgesic effects caused by imagination and observation with or without the presence of transcranial direct current (tDCS) in healthy participants. The secondary objective of this research is to evaluate the possible relationships between hypoalgesic effects and different physical and cognitive variables such as the ability to generate motor mental images, mental chronometry and levels of physical activity.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 65 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* asymptomatic participants
* men and women aged 18 to 65 years

Exclusion Criteria:

* insomnia
* nausea
* headache
* pregnant woman
* use of painkillers in the last twenty four hours
* presence of metal inside the head
* pacemaker
* wound on the area of electrodes' application
* drugs consumer
* recent application of transcranial direct stimulation
* psychiatric disease who lead the subject to a misunderstand of the study
```

## Arms

- **transcranial direct current plus Brain training tools** (EXPERIMENTAL) — 20 minutes of transcranial direct current stimulation along with the application of motor imagery and action observation
- **Placebo transcranial direct current plus Brain training tools** (PLACEBO_COMPARATOR) — A placebo intervention of direct transcranial stimulation being active during 15 seconds and then it will be turned off the rest of the time until 20 minutes. This group will also carry out the training of action observation and motor imagery.
- **Brain training tools in isolation** (SHAM_COMPARATOR) — This group will act as a control, they will only carry out the training of action observation and motor imagery.

## Interventions

- **Sooma transcranial direct current stimulation device plus Brain training tools** (DEVICE) — This group will carry out an observation training of actions and motor imagery in combination with the stimulation of the transcranial direct current.
- **Placebo Sooma transcranial direct current stimulation deviceplus Brain training tools** (DEVICE) — This group will carry out an observation training of actions and motor imagery in combination with the placebo stimulation of the transcranial direct current, where it will be acrtivo during 15 seconds and then it will be turned off during the rest of the intervention.
- **Brain training tools in isolation** (BEHAVIORAL) — This group will act as a control, they will only carry out the training of action observation and motor imagery.

## Primary Outcomes

- **Pressure pain threshold** _(time frame: Change in Pressure pain threshold just before the start of the intervention, immediately at the end of the intervention and 15 minutes after the end of the intervention)_ — Pressure pain threshold has been defined as the minimal amount of pressure at which a sense of pressure first changes to pain or discomfort

## Secondary Outcomes

- **Ability to generate motor images** _(time frame: Just before the start of the intervention)_
- **Mental Chronometry** _(time frame: Just before the start of the intervention)_
- **The degree of physical activity** _(time frame: Just before the start of the intervention)_

## Locations (1)

- CSEU La Salle, Madrid, Spain

## Recent Field Changes (last 30 days)

- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `sponsor.collaborators` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.cseu la salle|madrid||spain` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT04127253.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT04127253*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*