---
title: A Multi-center RCT Study on the Efficacy and Mechanism of Multi-channel tDCS in Rehabilitation of Cognitive Function After Stroke
nct_id: NCT04133714
overall_status: UNKNOWN
phase: NA
sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
study_type: INTERVENTIONAL
primary_condition: Cognitive Dysfunction
countries: China
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04133714.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04133714"
ct_last_update_post_date: 2020-10-29
last_seen_at: "2026-05-12T07:27:08.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# A Multi-center RCT Study on the Efficacy and Mechanism of Multi-channel tDCS in Rehabilitation of Cognitive Function After Stroke

**NCT ID:** [NCT04133714](https://clinicaltrials.gov/study/NCT04133714)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 180
- **Lead Sponsor:** Second Affiliated Hospital, School of Medicine, Zhejiang University
- **Conditions:** Cognitive Dysfunction
- **Start Date:** 2020-11-01
- **Completion Date:** 2023-12
- **CT.gov Last Update:** 2020-10-29

## Brief Summary

This clinical RCT study intends to combined different forms of multi-channel tDCS with the routine cognitive training process to treat patients with post-stroke cognitive dysfunction.

The therapeutic effects among single-channel tDCS group, multi-channel tDCS and pseudo-multichannel tDCS group will be compared. Brain magnetic resonance mechanism research will also be included to reveal the possible mechanism of multi-channel tDCS technology for PSCI brain network.

Thus, the efficacy and mechanism of multi-channel tDCS in post-stroke cognitive function rehabilitation will be researched both in the clinical and basic levels.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 60 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* 18-60 year-old
* diagnosed cerebral apoplexy, meeting the diagnostic criteria of ICD-10
* cognitive function, perceptual function decline after stroke
* first onset and duration of 3-12 months
* right-handed
* MMSE ≤25
* MoCA ≤25
* sign informed consent voluntarily and comply with the study plan

Exclusion Criteria:

* NIHSS ≥21 points
* MoCA ≤18, or DRS-2 ≤ 124, or CES-D ≥ 16
* taking drugs that affect central nervous activity, such as nerve antagonists
* specific contraindication, such as electrode patch allergy, local skin injury or - - - - inflammation, and hyperalgesia in stimulated areas
* patients use implantable electronic devices (such as cardiac pacemakers) or have - metal implants such as stents that affect MRI examination
* patients with a previous history of epilepsy, mental illness or skull injury
* patients with dementia or obvious cognitive dysfunction before stroke
* patients with aphasia or dysarthria and cannot complete the scale evaluation
* pregnancy
```

## Arms

- **multi-channel tDCS** (EXPERIMENTAL) — In the multi-channel tDCS stimulation group, a 1:4 (anode: cathode) approach was applied, with the central anode placed in the left dorsolateral prefrontal cortex (dlPFC) (reference 10-20 standard lead EEG), and the remaining cathode distributed around the central electrode.

The rising time and falling time of current are 30 seconds respectively. Stimulate 30 minutes daily for 10 days (Monday to Friday, once a day, weekend off).
- **single-channel tDCS** (EXPERIMENTAL) — The anode electrode of the single-channel tDCS stimulation group was placed in the left dlPFC, and the cathode electrode was placed in the right orbital forehead.

The rising time and falling time of current are 30 seconds respectively. Stimulate 30 minutes daily for 10 days (Monday to Friday, once a day, weekend off).
- **sham stimulation** (SHAM_COMPARATOR) — The shame stimulation group had only 30 seconds of up and down stimulation, with no intermediate stimulation.

## Interventions

- **multi-channel tDCS** (DEVICE) — multi-channel transcranial direct current stimulation, tDCS
- **single-channel tDCS** (DEVICE) — single-channel transcranial direct current stimulation

## Primary Outcomes

- **MMSE** _(time frame: Change from Baseline MMSE at 2 weeks and 3 months after intervention)_ — Mini-mental State Examination
- **MoCA** _(time frame: Change from Baseline MoCA at 2 weeks and 3 months after intervention)_ — Montreal Cognitive Assessment
- **AVLT** _(time frame: Change from Baseline AVLT at 2 weeks and 3 months after intervention)_ — The Auditory-Verbal Learning Test
- **WAIS-DST** _(time frame: Change from Baseline WAIS-DST at 2 weeks and 3 months after intervention)_ — WAIS Digit Symbol Test

## Secondary Outcomes

- **DEX** _(time frame: Change from Baseline DEX at 2 weeks and 3 months after intervention)_
- **GNAT** _(time frame: Change from Baseline GNAT at 2 weeks and 3 months after intervention)_

## Locations (4)

- Rainbowfish Rehabilitation Nursing Care, Hangzhou, Zhejiang, China — _RECRUITING_
- SAHZhejiangU, Hangzhou, Zhejiang, China — _RECRUITING_
- Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China — _RECRUITING_
- Southwest Hospital, Chongqing, China — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.rainbowfish rehabilitation nursing care|hangzhou|zhejiang|china` — added _(2026-05-12)_
- `locations.sahzhejiangu|hangzhou|zhejiang|china` — added _(2026-05-12)_
- `locations.zhejiang provincial people's hospital|hangzhou|zhejiang|china` — added _(2026-05-12)_
- `locations.southwest hospital|chongqing||china` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT04133714*  
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