---
title: Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis
nct_id: NCT04507009
overall_status: COMPLETED
phase: NA
sponsor: Ordu University
study_type: INTERVENTIONAL
primary_condition: Alveolar Osteitis
countries: Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04507009.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04507009"
ct_last_update_post_date: 2022-11-09
last_seen_at: "2026-05-12T06:36:26.016Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis

**Official Title:** Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis

**NCT ID:** [NCT04507009](https://clinicaltrials.gov/study/NCT04507009)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 60
- **Lead Sponsor:** Ordu University
- **Conditions:** Alveolar Osteitis
- **Start Date:** 2020-08-01
- **Completion Date:** 2022-10-01
- **CT.gov Last Update:** 2022-11-09

## Brief Summary

The aim of this study is to investigate the efficacy of CGF and Ozone in the treatment of alveolitis and to develop a new treatment protocol that can enable a quick and effective solution of this clinical problem, which significantly affects patients' comfort of life.

## Detailed Description

In the present study, 60 healthy patients \> 18 years old and have alveolitis, will included. 60 patient will divided randomly into three groups as Control, Ozone and Ozone+CGF. After irrigation of the sockets alvogyl, ozone and ozone+CGF will applied to the sockets respectively. Post operative pain, will measured at 1st to 7th days. Post operative infection, and granulation tissue will measured at 1st, 3rd and 7th days. Oral hygiene will evaluated at first visit. Quality of life will evaluated at 7th day.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 90 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

Patients who have one or more of the following in addition to severe pain, which occur within and around the socket 1-3 days after extraction and do not decrease with pain killers;

* With a partially or completely disintegrated blood clot in the socket
* With exposed bone that gives a dark gray appearance
* With bad odor

Exclusion Criteria:

* Who does not want to be volunteer for the study,
* Smokers,
* During pregnancy or lactation,
* Has a chronic systemic disorder that will affect recovery,
* Has hematological disorder
* Cooperation cannot be established,
* Previously received radiotherapy or chemotherapy,
* Patients using oral contraceptives
```

## Arms

- **Control** (ACTIVE_COMPARATOR) — Traditional treatment group which alvogyl applied to the socket after irrigation
- **Ozone** (EXPERIMENTAL) — Ozone group which Ozone (O3) applied after irrigation of the socket
- **CGF +Ozone** (EXPERIMENTAL) — CGF + Ozone group which concentrated growth factor (CGF) after Ozone (O3) applied followed by irrigation of the socket.

## Interventions

- **Ozone** (DEVICE) — topical gaseous ozone application
- **CGF** (OTHER) — concentrated growth factor (CGF) application
- **Traditional treatment** (OTHER) — Alvogyl application

## Primary Outcomes

- **Change in post-operative pain assessed: visual analog (VAS) scale** _(time frame: 6th and 24th hour, 2nd day, 3rd day, 4th day, 5th day, 6th day and 7th day)_ — For the evaluation of the pain, the visual analog scale (VAS) will be used to express the absence of pain in the initial part on a straight line (0) and the end part to express the unbearable pain (10).

0 (no pain)--------------------------------------------------------------------------------10 (unbearable pain) Higher values of the scale represent worse outcome.

## Secondary Outcomes

- **Granulation tissue health** _(time frame: postoperative 1st, 3rd, 7th days)_
- **Inflamation severity** _(time frame: postoperative 1st, 3rd, 7th days)_
- **Change in the quality of postoperative life after the procedures performed** _(time frame: postoperative 7th day)_

## Locations (1)

- Ordu University, Ordu, Turkey (Türkiye)

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.ordu university|ordu||turkey (türkiye)` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT04507009*  
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