---
title: "\"Syringe Free\" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Central Venous Catheter Placement"
nct_id: NCT04684069
overall_status: COMPLETED
phase: NA
sponsor: Ataturk University
study_type: INTERVENTIONAL
primary_condition: Catheter Complications
countries: Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04684069.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04684069"
ct_last_update_post_date: 2020-12-28
last_seen_at: "2026-05-12T06:19:36.914Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# "Syringe Free" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Central Venous Catheter Placement

**Official Title:** "Syringe Free" Long-Axis In-Plane vs. Short-Axis Out-of-Plane Approach for Ultrasound-Guided Central Venous Catheter Placement in Critically Ill Children: A Prospective Randomized Study

**NCT ID:** [NCT04684069](https://clinicaltrials.gov/study/NCT04684069)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 60
- **Lead Sponsor:** Ataturk University
- **Conditions:** Catheter Complications, Critical Illness
- **Start Date:** 2020-07-01
- **Completion Date:** 2020-12-15
- **CT.gov Last Update:** 2020-12-28

## Brief Summary

Internal jugular, subclavian, or femoral veins are often used for central venous catheter (CVC) placement. Regardless of which vein is preferred, the "Seldinger" technique is used most frequently. The most commonly used method with ultrasound is the short-axis out-of-plane approach. The main problem in this method is that the correct needle tip is missed, and it causes some complications by causing posterior wall punctures. The "Syringe-free" technique is first reported by Matias et al. in adults; it is a technique that allows full real-time monitoring of the guidewire insertion into the vein without blood aspiration. It is a great advantage in CVC placement, especially with the long-axis in-plane approach. When the literature is reviewed, no study other than a 12 case study in which brachiocephalic vein catheterization related to CVC placement was performed using this technique in children was found. There is no randomized study comparing the "Syringe-free" Long-Axis In-Plane technique with the classic Short-Axis Out-of-Plane technique in pediatric patients.

This study compares these two techniques' efficacy and complication rates in critically ill children requiring CVC placement.

## Eligibility

- **Minimum age:** 3 Months
- **Maximum age:** 15 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patients older than 3 months, younger than 15 years old
* Critical illness pediatrics

Exclusion Criteria:

* Patients younger than 3 months and older than 15 years,
* body weight less than 5000 gr,
* anatomical malformation in the neck,
* infection at the intervention site,
* thrombosis
```

## Arms

- **syringe free long axis in-plane** (ACTIVE_COMPARATOR)
- **Short axis out-of-plane** (SHAM_COMPARATOR)

## Interventions

- **Long-axis syringe free in-plane** (DEVICE) — Long-axis syringe-free in-plane catheter placement
- **Short-axis out-of-plane** (DEVICE) — Short-axis out-of-plane catheter placement

## Primary Outcomes

- **Performing time** _(time frame: First 10 minutes)_ — The time between the insertion of the needle through the skin and insertion of the guidewire into the internal jugular vein.

## Secondary Outcomes

- **Complications** _(time frame: First 24 hours)_
- **Number of neddle pass** _(time frame: First 10 minutes)_
- **First pass success** _(time frame: First 10 minutes)_
- **New puncture** _(time frame: First 10 minutes)_

## Locations (1)

- Ataturk University, Erzurum, Turkey (Türkiye)

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.ataturk university|erzurum||turkey (türkiye)` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT04684069.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT04684069*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*