---
title: Association Between Human Immunodeficiency Virus (HIV) Infection and Male Hypogonadism
nct_id: NCT04760574
overall_status: RECRUITING
sponsor: National Taiwan University Hospital
study_type: OBSERVATIONAL
primary_condition: Hypogonadism; Ovarian
countries: Taiwan
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04760574.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04760574"
ct_last_update_post_date: 2021-03-03
last_seen_at: "2026-05-12T06:52:29.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Association Between Human Immunodeficiency Virus (HIV) Infection and Male Hypogonadism

**NCT ID:** [NCT04760574](https://clinicaltrials.gov/study/NCT04760574)

## Key Facts

- **Status:** RECRUITING
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 1200
- **Lead Sponsor:** National Taiwan University Hospital
- **Conditions:** Hypogonadism; Ovarian
- **Start Date:** 2021-02-02
- **Completion Date:** 2030-11
- **CT.gov Last Update:** 2021-03-03

## Brief Summary

Cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population

## Detailed Description

In this study, we conduct a cross-sectional study investigating the prevalence of hypogonadism in HIV-infected MSM population. Age-matched non-HIV infected MSM group will be used as comparison group. We will also determine the risk factors associated with male hypogonadism (age, duration of HIV infection, comorbidities, BMI, ART use). Correlation will be made between serum testosterone levels and sexual function, vitality, exercise capacity, mood, and bone mineral density.

## Eligibility

- **Minimum age:** 20 Years
- **Sex:** MALE
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* HIV-infected men who have sex with men
* HIV non-infected men

Exclusion Criteria:

* Use of testosterone supplement, anabolic steroid in the past one year.
* History of pituitary , adrenal or gonad diseases
* History of pituitary surgery or radiation therapy
* History of systemic chemotherapy
* Active opportunistic infection under treatment
* Cancer
* Severe hepatic, renal or cardiac impairment
```

## Arms

- **Case group** — HIV infected men who have sex with men
- **Control group** — HIV non-infected men

## Interventions

- **Testosterone** (DIAGNOSTIC_TEST) — Serum total testosterone and free testosterone level

## Primary Outcomes

- **Symptoms of androgen deficiency** _(time frame: 2021-2030)_ — We use the score of Androgen Deficiency in Aging Males (ADAM) questionnaire to study the prevalence of hypogonadism in HIV-infected MSM population
- **Serum free testosterone** _(time frame: 2021-2030)_ — We use serum free testosterone to study the prevalence of hypogonadism in HIV-infected MSM population

## Locations (1)

- National Taiwan University Hospital, Taipei, Taiwan — _RECRUITING_

## Recent Field Changes (last 30 days)

- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.national taiwan university hospital|taipei||taiwan` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT04760574.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT04760574*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*