---
title: Influence of Tart Cherry Juice Intervention on Vascular Function
nct_id: NCT04840160
overall_status: COMPLETED
phase: NA
sponsor: Northumbria University
study_type: INTERVENTIONAL
primary_condition: Dietary Exposure
countries: United Kingdom
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04840160.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04840160"
ct_last_update_post_date: 2021-04-09
last_seen_at: "2026-05-12T06:56:03.585Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Influence of Tart Cherry Juice Intervention on Vascular Function

**Official Title:** Influence of Tart Cherry Juice Intervention on Vascular Function and the Urinary Metabolite; a Preliminary Study to Inform Study Design

**NCT ID:** [NCT04840160](https://clinicaltrials.gov/study/NCT04840160)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 23
- **Lead Sponsor:** Northumbria University
- **Conditions:** Dietary Exposure, Metabolic Disturbance
- **Start Date:** 2016-04-01
- **Completion Date:** 2019-08-01
- **CT.gov Last Update:** 2021-04-09

## Brief Summary

Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action

## Detailed Description

Cardiovascular disease (CVD) is the primary cause of morbidity and mortality. Tart cherries (TC) can positively impact major risk factors of CVD, activities thought to be related to their phytochemical content. However, data from human trials is less clear. TC have been shown to reduce systolic blood pressure (SBP) after acute, short-term and chronic intake, and to improve vascular dysfunction, presumably due to their antioxidant and anti-inflammatory activities. Other studies have not shown benefits of TC on SBP or vascular function and studies are difficult to interpret with different populations, dosing and durations being used as well as a lack of understanding for any underlying mechanisms. To account for the latter, the use of metabolomics has become increasingly popular in nutritional research. Therefore, the aim of this preliminary study was to characterise the effects of TC supplementation on vascular function with a 4-week intervention and explore if metabolomics can provide mechanistic evidence and this will inform for future chronic studies with TC juice.

## Eligibility

- **Minimum age:** 19 Years
- **Maximum age:** 40 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* aged 19-40
* no diagnosed issues with the ability to consume fruit juice
* no known food intolerances to fruits

Exclusion Criteria:

* participants that are cigarette smokers
* participants diagnosed with hypertension
* participants diagnosed with any form of cardiometabolic diseases
* participants that require any prescribed prescriptions excluding the contraceptive pill
* participants that are regular consumers of cherries (\>100 g/d)
* participants that consume any antioxidant supplements
```

## Arms

- **Placebo** (PLACEBO_COMPARATOR) — Participants supplied with 30 ml of a low fruit (\<1%) cordial mixed with maltodextrin and protein diluted in 100 ml water twice daily, once in the morning and evening.
- **Cherry juice** (EXPERIMENTAL) — Participants supplied with 30 ml of a tart cherry juice concentrate (CherryActive, United Kingdom; (containing 36.8 mg of anthocyanins) diluted in 100 ml of water twice daily, once in the morning and evening.

## Interventions

- **Cherry juice** (DIETARY_SUPPLEMENT) — A tart cherry juice intervention
- **Placebo** (DIETARY_SUPPLEMENT) — A tart cherry juice placebo

## Primary Outcomes

- **Systolic and diastolic blood pressure** _(time frame: Change in blood pressure following 4 weeks intervention)_ — Measurement of systolic and diastolic blood pressure before and after the intervention
- **Arterial pulse wave velocity** _(time frame: Change in pulse wave velocity following 4 weeks intervention)_ — Measurement of pulse wave velocity before and after the intervention
- **Digital volume pulse** _(time frame: Change in digital volume pulse following 4 weeks intervention)_ — Measurement of digital volume pulse before and after the intervention

## Secondary Outcomes

- **Metabolomics** _(time frame: Changes to urinary metabolite profiles following 4 weeks intervention)_

## Locations (1)

- Northumberland Building, Newcastle upon Tyne, United Kingdom

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.northumberland building|newcastle upon tyne||united kingdom` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT04840160.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT04840160*  
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