--- title: Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors nct_id: NCT04871542 overall_status: RECRUITING sponsor: SWOG Cancer Research Network study_type: OBSERVATIONAL primary_condition: Malignant Solid Neoplasm countries: United States, Chile, Guam, Mexico, Uruguay canonical_url: "https://parkinsonspathways.com/agent/trials/NCT04871542.md" clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT04871542" ct_last_update_post_date: 2026-05-05 last_seen_at: "2026-05-12T07:03:30.385Z" source: ClinicalTrials.gov (mirrored, no enrichment) --- # Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors **Official Title:** Immune Checkpoint Inhibitor Toxicity (I-CHECKIT): A Prospective Observational Study **NCT ID:** [NCT04871542](https://clinicaltrials.gov/study/NCT04871542) ## Key Facts - **Status:** RECRUITING - **Study Type:** OBSERVATIONAL - **Target Enrollment:** 2062 - **Lead Sponsor:** SWOG Cancer Research Network - **Collaborators:** National Cancer Institute (NCI) - **Conditions:** Malignant Solid Neoplasm - **Start Date:** 2021-09-13 - **Completion Date:** 2028-03-14 - **CT.gov Last Update:** 2026-05-05 ## Brief Summary This study examines how certain risk factors (such as age, gender, other medical conditions, and the type of immunotherapy used to treat the cancer) affect whether a patient with a malignant solid tumor will develop mild or serious side effects from the immunotherapy medications. Immunotherapy is the type of treatment that helps the body's immune system fight cancer. In the future, this information may help doctors make better decisions about cancer treatments. ## Detailed Description PRIMARY OBJECTIVE: I. To both develop and independently validate a risk prediction model for Common Terminology Criteria for Adverse Events (CTCAE) grade 3 or higher non-hematological immune-related adverse events (irAEs) in the first year of immune checkpoint inhibitor (ICI)-based therapy for the treatment of solid tumors. SECONDARY OBJECTIVES: I. To prospectively assess the incidence of any grade of non-hematological irAEs and grade 4 hematological irAEs on ICI-based therapy. II. To observe the trajectory of patient-reported quality of life and health preferences over 12 months. III. To observe the trajectory of patient-reported adverse events over 12 months using serial assessment with select Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) measures. IV. To measure the burden of chronic, grade 1 and 2 toxicities using methods such as toxicity over time (ToxT). V. To track patterns of treatment of irAEs and patterns of toxicity resolution. TRANSLATIONAL MEDICINE OBJECTIVES: I. To evaluate the cytokine toxicity (CYTOX) score, a composite measure derived from 11 different cytokine levels, both prior to ICI-based therapy and after 1 cycle of ICI-based therapy as a predictive signature for the development of irAEs. II. To establish a repository of archival tissue and blood/serum specimens for potential predictive and/or prognostic markers of irAE risk. ADDITIONAL OBJECTIVE: I. To assess the feasibility of using electronic (e)PRO in a multi-center clinical trial setting. OUTLINE: Patients undergo collection of a tissue sample at the start of their routine cancer treatment. Patients complete questionnaires at the start of cancer treatment, weeks 4, 12, 24, and 52. Patients will have the option of providing blood samples at several time points during the study. ## Eligibility - **Minimum age:** 18 Years - **Sex:** ALL - **Healthy Volunteers:** No ``` Inclusion Criteria: * Participants must be planning to receive ICI-based therapy for a solid tumor malignancy. This therapy must be given according to Food and Drug Administration (FDA) label or National Comprehensive Cancer Network (NCCN) guidelines at Category 1 or 2A and not in the context of a clinical trial * Participants who have received prior ICI-based therapy must have completed ICI based therapy at least 180 days prior to registration * Participants must not have discontinued any prior ICI-based therapy (if applicable) because of irAE * Participants must not have received chemotherapy, biologic, or targeted-therapy within 21 days prior to registration * Participants must have recovered from side effects of prior therapy to the following standards per treating physician's discretion: * =\< Grade 1 for any non-hematologic side effects (excluding neuropathy and alopecia); lab-related parameters of liver and renal function will be considered at the discretion of the treating physician) * =\< Grade 2 for neuropathy and/or alopecia * Grade 3 or less for any hematologic side effects * Participants must be planning to begin standard of care ICI-based therapy within 3 calendar days after registration * Participants must not be planning to receive ICI-based therapy in combination with chemotherapy or any other non-ICI therapy for treatment of their cancer * Participants must be at least 18 years of age * Participants must complete their history and physical examination within 28 days prior to registration * Participants who can complete the S2013 Feasibility Questionnaire in English or Spanish must participate at the scheduled assessments * Participants must be able to complete Patient-Reported Outcome (PRO) instruments in English, Spanish, or French and must be planning to complete PROs at all scheduled assessments * Participants must complete the pre-registration (baseline) PRO forms within 14 days prior to registration * Participants must be willing to participate in PRO data collection * Note: Prior to registration, participants must decide on their method (paper or electronic) of completing their follow-up questionnaires. Participants who elect electronic (ePRO) completion must have an iPhone, Android phone, or tablet with cellular or WiFi connectivity in order to download the Patient Cloud mobile applications onto the device (personal device or a site provisioned device for multi-users) * Participants must be offered the opportunity to participate in the optional specimen banking * Note: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system. * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines ``` ## Arms - **Observational (biospecimen collection, questionnaire)** — Patients undergo collection of a tissue sample at the start of their routine cancer treatment. Patients complete questionnaires at the start of cancer treatment, weeks 4, 12, 24, and 52. Patients will have the option of providing blood samples at several time points during the study. ## Interventions - **Biospecimen Collection** (PROCEDURE) — Undergo collection of blood sample - **Questionnaire Administration** (OTHER) — Complete questionnaires ## Primary Outcomes - **Occurrence of severe or worse non-hematological immune-related adverse event (irAE)** _(time frame: 52 weeks)_ — Adverse events will be recorded according to the physician rated Common Terminology Criteria for Adverse Events (CTCAE) scoring system. ## Secondary Outcomes - **Change in Patient-Reported Outcomes Measurement Information System (PROMIS)-29** _(time frame: Baseline to 52 weeks)_ - **Change in PRO-CTCAE scores** _(time frame: Baseline to 52 weeks)_ - **Change in PROMIS Cognitive Function- Short Form 4a version 2.0 scores** _(time frame: Baseline to 52 weeks)_ - **Change in toxicity over time (ToxT)** _(time frame: Baseline to 52 weeks)_ - **Change in cytokine toxicity (CYTOX) score** _(time frame: Baseline to 1 cycle after ICI-therapy)_ ## Locations (849) - Anchorage Associates in Radiation Medicine, Anchorage, Alaska, United States — _RECRUITING_ - Anchorage Radiation Therapy Center, Anchorage, Alaska, United States — _SUSPENDED_ - Alaska Breast Care and Surgery LLC, Anchorage, Alaska, United States — _RECRUITING_ - Alaska Oncology and Hematology LLC, Anchorage, Alaska, United States — _RECRUITING_ - Alaska Women's Cancer Care, Anchorage, Alaska, United States — _RECRUITING_ - Anchorage Oncology Centre, Anchorage, Alaska, United States — _SUSPENDED_ - Katmai Oncology Group, Anchorage, Alaska, United States — _RECRUITING_ - Providence Alaska Medical Center, Anchorage, Alaska, United States — _RECRUITING_ - Fairbanks Memorial Hospital, Fairbanks, Alaska, United States — _SUSPENDED_ - Kingman Regional Medical Center, Kingman, Arizona, United States — _RECRUITING_ - Cancer Center at Saint Joseph's, Phoenix, Arizona, United States — _RECRUITING_ - Banner University Medical Center - Tucson, Tucson, Arizona, United States — _SUSPENDED_ - University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States — _SUSPENDED_ - Onvida Health Yuma Medical Center, Yuma, Arizona, United States — _SUSPENDED_ - Mercy Hospital Fort Smith, Fort Smith, Arkansas, United States — _RECRUITING_ - CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas, United States — _SUSPENDED_ - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas, United States — _RECRUITING_ - CARTI Cancer Center, Little Rock, Arkansas, United States — _RECRUITING_ - Kaiser Permanente-Deer Valley Medical Center, Antioch, California, United States — _RECRUITING_ - Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California, United States — _RECRUITING_ - PCR Oncology, Arroyo Grande, California, United States — _RECRUITING_ - Keck Medicine of USC Buena Park, Buena Park, California, United States — _SUSPENDED_ - Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States — _RECRUITING_ - Marshall Cancer Center, Cameron Park, California, United States — _SUSPENDED_ - Mercy Cancer Center - Carmichael, Carmichael, California, United States — _RECRUITING_ - Mercy San Juan Medical Center, Carmichael, California, United States — _RECRUITING_ - Kaiser Permanente Dublin, Dublin, California, United States — _RECRUITING_ - Mercy Cancer Center - Elk Grove, Elk Grove, California, United States — _RECRUITING_ - Kaiser Permanente-Fremont, Fremont, California, United States — _RECRUITING_ - VA Central California Fresno Medical Center, Fresno, California, United States — _RECRUITING_ - Fresno Cancer Center, Fresno, California, United States — _RECRUITING_ - Kaiser Permanente Fresno Orchard Plaza, Fresno, California, United States — _RECRUITING_ - Kaiser Permanente-Fresno, Fresno, California, United States — _RECRUITING_ - Keck Medicine of USC Huntington Beach, Huntington Beach, California, United States — _SUSPENDED_ - Tibor Rubin VA Medical Center, Long Beach, California, United States — _SUSPENDED_ - Keck Medicine of USC Koreatown, Los Angeles, California, United States — _SUSPENDED_ - Los Angeles General Medical Center, Los Angeles, California, United States — _SUSPENDED_ - USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States — _ACTIVE_NOT_RECRUITING_ - Contra Costa Regional Medical Center, Martinez, California, United States — _RECRUITING_ - Fremont - Rideout Cancer Center, Marysville, California, United States — _SUSPENDED_ - Mercy Cancer Center, Merced, California, United States — _RECRUITING_ - Kaiser Permanente- Modesto MOB II, Modesto, California, United States — _RECRUITING_ - Kaiser Permanente-Modesto, Modesto, California, United States — _RECRUITING_ - Providence Queen of The Valley, Napa, California, United States — _RECRUITING_ - USC Norris Oncology/Hematology-Newport Beach, Newport Beach, California, United States — _SUSPENDED_ - Kaiser Permanente Oakland-Broadway, Oakland, California, United States — _RECRUITING_ - Kaiser Permanente-Oakland, Oakland, California, United States — _RECRUITING_ - Keck Medical Center of USC Pasadena, Pasadena, California, United States — _SUSPENDED_ - Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California, United States — _RECRUITING_ - Eisenhower Medical Center, Rancho Mirage, California, United States — _SUSPENDED_ - Kaiser Permanente- Marshall Medical Offices, Redwood City, California, United States — _RECRUITING_ - Kaiser Permanente-Richmond, Richmond, California, United States — _RECRUITING_ - Mercy Cancer Center - Rocklin, Rocklin, California, United States — _RECRUITING_ - Rohnert Park Cancer Center, Rohnert Park, California, United States — _RECRUITING_ - Kaiser Permanente-Roseville, Roseville, California, United States — _RECRUITING_ - The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California, United States — _RECRUITING_ - Kaiser Permanente Downtown Commons, Sacramento, California, United States — _RECRUITING_ - Mercy Cancer Center - Sacramento, Sacramento, California, United States — _RECRUITING_ - Kaiser Permanente-South Sacramento, Sacramento, California, United States — _RECRUITING_ - South Sacramento Cancer Center, Sacramento, California, United States — _RECRUITING_ - Kaiser Permanente-San Francisco, San Francisco, California, United States — _RECRUITING_ - Veterans Affairs Medical Center - San Francisco, San Francisco, California, United States — _SUSPENDED_ - Kaiser Permanente-Santa Teresa-San Jose, San Jose, California, United States — _RECRUITING_ - Kaiser Permanente San Leandro, San Leandro, California, United States — _RECRUITING_ - Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California, United States — _RECRUITING_ - Kaiser San Rafael-Gallinas, San Rafael, California, United States — _RECRUITING_ - Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States — _RECRUITING_ - Mission Hope Medical Oncology - Santa Maria, Santa Maria, California, United States — _RECRUITING_ - Kaiser Permanente-Santa Rosa, Santa Rosa, California, United States — _RECRUITING_ - Providence Medical Foundation - Santa Rosa, Santa Rosa, California, United States — _RECRUITING_ - Providence Santa Rosa Memorial Hospital, Santa Rosa, California, United States — _RECRUITING_ - Kaiser Permanente Cancer Treatment Center, South San Francisco, California, United States — _RECRUITING_ - Kaiser Permanente-South San Francisco, South San Francisco, California, United States — _RECRUITING_ - Kaiser Permanente-Stockton, Stockton, California, United States — _RECRUITING_ - Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California, United States — _SUSPENDED_ - Kaiser Permanente Medical Center-Vacaville, Vacaville, California, United States — _RECRUITING_ - Kaiser Permanente-Vallejo, Vallejo, California, United States — _RECRUITING_ - Kaiser Permanente-Walnut Creek, Walnut Creek, California, United States — _RECRUITING_ - BASS Medical Group - Lennon, Walnut Creek, California, United States — _RECRUITING_ - Woodland Memorial Hospital, Woodland, California, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, United States — _RECRUITING_ - The Medical Center of Aurora, Aurora, Colorado, United States — _SUSPENDED_ - Rocky Mountain Regional VA Medical Center, Aurora, Colorado, United States — _SUSPENDED_ - Boulder Community Foothills Hospital, Boulder, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers - Centennial, Centennial, Colorado, United States — _RECRUITING_ - Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado, United States — _RECRUITING_ - Saint Francis Cancer Center, Colorado Springs, Colorado, United States — _RECRUITING_ - Cancer Center of Colorado at Sloan's Lake, Denver, Colorado, United States — _SUSPENDED_ - Kaiser Permanente-Franklin, Denver, Colorado, United States — _RECRUITING_ - National Jewish Health-Main Campus, Denver, Colorado, United States — _SUSPENDED_ - The Women's Imaging Center, Denver, Colorado, United States — _RECRUITING_ - AdventHealth Porter, Denver, Colorado, United States — _SUSPENDED_ - Colorado Blood Cancer Institute, Denver, Colorado, United States — _RECRUITING_ - Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Midtown, Denver, Colorado, United States — _RECRUITING_ - Saint Joseph Hospital - Cancer Centers of Colorado, Denver, Colorado, United States — _SUSPENDED_ - Rocky Mountain Cancer Centers-Rose, Denver, Colorado, United States — _RECRUITING_ - Rose Medical Center, Denver, Colorado, United States — _SUSPENDED_ - Western Surgical Care, Denver, Colorado, United States — _SUSPENDED_ - CommonSpirit Cancer Center Mercy, Durango, Colorado, United States — _RECRUITING_ - Mercy Medical Center, Durango, Colorado, United States — _RECRUITING_ - Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado, United States — _SUSPENDED_ - Rocky Mountain Cancer Centers - Swedish, Englewood, Colorado, United States — _RECRUITING_ - Swedish Medical Center, Englewood, Colorado, United States — _SUSPENDED_ - The Melanoma and Skin Cancer Institute, Englewood, Colorado, United States — _RECRUITING_ - Poudre Valley Hospital, Fort Collins, Colorado, United States — _SUSPENDED_ - Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado, United States — _SUSPENDED_ - National Jewish Health-Western Hematology Oncology, Golden, Colorado, United States — _SUSPENDED_ - Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, United States — _SUSPENDED_ - Grand Valley Oncology, Grand Junction, Colorado, United States — _SUSPENDED_ - Banner North Colorado Medical Center, Greeley, Colorado, United States — _SUSPENDED_ - UCHealth Greeley Hospital, Greeley, Colorado, United States — _SUSPENDED_ - Good Samaritan Hospital - Cancer Centers of Colorado, Lafayette, Colorado, United States — _SUSPENDED_ - Kaiser Permanente-Rock Creek, Lafayette, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado, United States — _RECRUITING_ - Saint Anthony Hospital, Lakewood, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, United States — _RECRUITING_ - AdventHealth Littleton, Littleton, Colorado, United States — _SUSPENDED_ - Kaiser Permanente-Lone Tree, Lone Tree, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado, United States — _RECRUITING_ - Sky Ridge Medical Center, Lone Tree, Colorado, United States — _SUSPENDED_ - Longmont United Hospital, Longmont, Colorado, United States — _RECRUITING_ - Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado, United States — _RECRUITING_ - Medical Center of the Rockies, Loveland, Colorado, United States — _SUSPENDED_ - Banner North Colorado Medical Center - Loveland Campus, Loveland, Colorado, United States — _SUSPENDED_ - AdventHealth Parker, Parker, Colorado, United States — _SUSPENDED_ - Saint Mary Corwin Medical Center, Pueblo, Colorado, United States — _RECRUITING_ - National Jewish Health-Northern Hematology Oncology, Thornton, Colorado, United States — _SUSPENDED_ - Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado, United States — _RECRUITING_ - Saint Anthony North Hospital, Westminster, Colorado, United States — _RECRUITING_ - Intermountain Health Lutheran Hospital, Wheat Ridge, Colorado, United States — _SUSPENDED_ - Hartford HealthCare - Avon, Avon, Connecticut, United States — _SUSPENDED_ - Danbury Hospital, Danbury, Connecticut, United States — _SUSPENDED_ - Hartford Hospital, Hartford, Connecticut, United States — _SUSPENDED_ - Hartford HealthCare - Manchester, Manchester, Connecticut, United States — _SUSPENDED_ - Midstate Medical Center, Meriden, Connecticut, United States — _SUSPENDED_ - The Hospital of Central Connecticut, New Britain, Connecticut, United States — _SUSPENDED_ - Norwalk Hospital, Norwalk, Connecticut, United States — _SUSPENDED_ - Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut, United States — _SUSPENDED_ - Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven, Connecticut, United States — _SUSPENDED_ - Beebe Medical Center, Lewes, Delaware, United States — _RECRUITING_ - Beebe South Coastal Health Campus, Millville, Delaware, United States — _RECRUITING_ - Delaware Clinical and Laboratory Physicians PA, Newark, Delaware, United States — _SUSPENDED_ - Helen F Graham Cancer Center, Newark, Delaware, United States — _RECRUITING_ - Medical Oncology Hematology Consultants PA, Newark, Delaware, United States — _RECRUITING_ - Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States — _RECRUITING_ - Beebe Health Campus, Rehoboth Beach, Delaware, United States — _RECRUITING_ - TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware, United States — _SUSPENDED_ - Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware, United States — _RECRUITING_ - Mount Sinai Comprehensive Cancer Center at Aventura, Aventura, Florida, United States — _RECRUITING_ - Schulze Family Foundation Cancer Clinic - Bonita Health Center, Bonita Springs, Florida, United States — _RECRUITING_ - Morton Plant Hospital, Clearwater, Florida, United States — _SUSPENDED_ - Broward Health North, Deerfield Beach, Florida, United States — _SUSPENDED_ - Holy Cross Hospital, Fort Lauderdale, Florida, United States — _RECRUITING_ - Broward Health Medical Center, Fort Lauderdale, Florida, United States — _SUSPENDED_ - Regional Cancer Center-Lee Memorial Health System, Fort Myers, Florida, United States — _RECRUITING_ - Mount Sinai Medical Center, Miami Beach, Florida, United States — _RECRUITING_ - Sacred Heart Hospital, Pensacola, Florida, United States — _SUSPENDED_ - South Florida Baptist Hospital, Plant City, Florida, United States — _SUSPENDED_ - Saint Anthony's Hospital Cancer Care Center, St. Petersburg, Florida, United States — _SUSPENDED_ - Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, United States — _SUSPENDED_ - Winter Haven Hospital, Winter Haven, Florida, United States — _SUSPENDED_ - Phoebe Putney Memorial Hospital, Albany, Georgia, United States — _RECRUITING_ - Augusta Oncology Associates PC-D'Antignac, Augusta, Georgia, United States — _RECRUITING_ - Augusta Oncology Associates PC-Wheeler, Augusta, Georgia, United States — _RECRUITING_ - Augusta University Medical Center, Augusta, Georgia, United States — _RECRUITING_ - Northeast Georgia Medical Center Braselton, Braselton, Georgia, United States — _RECRUITING_ - John B Amos Cancer Center, Columbus, Georgia, United States — _RECRUITING_ - Eisenhower Army Medical Center, Fort Eisenhower, Georgia, United States — _RECRUITING_ - Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia, United States — _RECRUITING_ - The Longstreet Clinic - Gainesville, Gainesville, Georgia, United States — _RECRUITING_ - Low Country Cancer Care, Savannah, Georgia, United States — _ACTIVE_NOT_RECRUITING_ - Memorial Health University Medical Center, Savannah, Georgia, United States — _ACTIVE_NOT_RECRUITING_ - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, United States — _RECRUITING_ - Tift Regional Medical Center, Tifton, Georgia, United States — _RECRUITING_ - Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii, United States — _SUSPENDED_ - Queen's Cancer Cenrer - POB I, Honolulu, Hawaii, United States — _SUSPENDED_ - Queen's Medical Center, Honolulu, Hawaii, United States — _SUSPENDED_ - Straub Clinic and Hospital, Honolulu, Hawaii, United States — _SUSPENDED_ - University of Hawaii Cancer Center, Honolulu, Hawaii, United States — _SUSPENDED_ - Hawaii Diagnostic Radiology Services LLC, Honolulu, Hawaii, United States — _SUSPENDED_ - Kuakini Medical Center, Honolulu, Hawaii, United States — _SUSPENDED_ - Queen's Cancer Center - Kuakini, Honolulu, Hawaii, United States — _SUSPENDED_ - The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii, United States — _SUSPENDED_ - Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii, United States — _RECRUITING_ - Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States — _SUSPENDED_ - Straub Medical Center - Kahului Clinic, Kahului, Hawaii, United States — _SUSPENDED_ - Castle Medical Center, Kailua, Hawaii, United States — _SUSPENDED_ - Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, United States — _SUSPENDED_ - Hawaii Cancer Care - Westridge, ‘Aiea, Hawaii, United States — _SUSPENDED_ - Pali Momi Medical Center, ‘Aiea, Hawaii, United States — _SUSPENDED_ - Queen's Cancer Center - Pearlridge, ‘Aiea, Hawaii, United States — _SUSPENDED_ - The Cancer Center of Hawaii-Pali Momi, ‘Aiea, Hawaii, United States — _SUSPENDED_ - The Queen's Medical Center - West Oahu, ‘Ewa Beach, Hawaii, United States — _SUSPENDED_ - Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States — _RECRUITING_ - Saint Luke's Cancer Institute - Boise, Boise, Idaho, United States — _RECRUITING_ - Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho, United States — _RECRUITING_ - Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho, United States — _RECRUITING_ - _and 649 more_ ## Recent Field Changes (last 30 days) - `locations.licking memorial hospital|newark|ohio|united states` — added _(2026-05-12)_ - `locations.newark radiation oncology|newark|ohio|united states` — added _(2026-05-12)_ - `locations.mercy health - perrysburg hospital|perrysburg|ohio|united states` — added _(2026-05-12)_ - `locations.southern ohio medical center|portsmouth|ohio|united states` — added _(2026-05-12)_ - `locations.legacy good samaritan hospital and medical center|portland|oregon|united states` — added _(2026-05-12)_ - `locations.springfield regional cancer center|springfield|ohio|united states` — added _(2026-05-12)_ - `locations.springfield regional medical center|springfield|ohio|united states` — added _(2026-05-12)_ - `locations.mercy health - saint vincent hospital|toledo|ohio|united states` — added _(2026-05-12)_ - `locations.mercy health - saint anne hospital|toledo|ohio|united states` — added _(2026-05-12)_ - `locations.mercy health sylvania radiation oncology center|toledo|ohio|united states` — added _(2026-05-12)_ - `locations.dayton physicians llc - troy|troy|ohio|united states` — added _(2026-05-12)_ - `locations.upper valley medical center|troy|ohio|united states` — added _(2026-05-12)_ - `locations.saint joseph warren hospital|warren|ohio|united states` — added _(2026-05-12)_ - `locations.saint ann's hospital|westerville|ohio|united states` — added _(2026-05-12)_ - `locations.clinton memorial hospital/foster j boyd regional cancer center|wilmington|ohio|united states` — added _(2026-05-12)_ - `locations.saint elizabeth youngstown hospital|youngstown|ohio|united states` — added _(2026-05-12)_ - `locations.genesis healthcare system cancer care center|zanesville|ohio|united states` — added _(2026-05-12)_ - `locations.mercy hospital oklahoma city|oklahoma city|oklahoma|united states` — added _(2026-05-12)_ - `locations.saint alphonsus cancer care center-baker city|baker city|oregon|united states` — added _(2026-05-12)_ - `locations.saint charles health system|bend|oregon|united states` — added _(2026-05-12)_ - `locations.clackamas radiation oncology center|clackamas|oregon|united states` — added _(2026-05-12)_ - `locations.kaiser sunnyside medical center|clackamas|oregon|united states` — added _(2026-05-12)_ - `locations.providence cancer institute clackamas clinic|clackamas|oregon|united states` — added _(2026-05-12)_ - `locations.bay area hospital|coos bay|oregon|united states` — added _(2026-05-12)_ - `locations.good samaritan hospital|corvallis|oregon|united states` — added _(2026-05-12)_ - `locations.legacy mount hood medical center|gresham|oregon|united states` — added _(2026-05-12)_ - `locations.providence newberg medical center|newberg|oregon|united states` — added _(2026-05-12)_ - `locations.saint alphonsus cancer care center-ontario|ontario|oregon|united states` — added _(2026-05-12)_ - `locations.providence willamette falls medical center|oregon city|oregon|united states` — added _(2026-05-12)_ - `locations.providence portland medical center|portland|oregon|united states` — added _(2026-05-12)_ - `locations.providence saint vincent medical center|portland|oregon|united states` — added _(2026-05-12)_ - `locations.kaiser permanente northwest|portland|oregon|united states` — added _(2026-05-12)_ - `locations.oregon health and science university|portland|oregon|united states` — added _(2026-05-12)_ - `locations.saint charles health system-redmond|redmond|oregon|united states` — added _(2026-05-12)_ - `locations.legacy meridian park hospital|tualatin|oregon|united states` — added _(2026-05-12)_ - `locations.lehigh valley hospital-cedar crest|allentown|pennsylvania|united states` — added _(2026-05-12)_ - `locations.lehigh valley hospital - muhlenberg|bethlehem|pennsylvania|united states` — added _(2026-05-12)_ - `locations.christiana care health system-concord health center|chadds ford|pennsylvania|united states` — added _(2026-05-12)_ - `locations.geisinger medical center|danville|pennsylvania|united states` — added _(2026-05-12)_ - `locations.doylestown hospital|doylestown|pennsylvania|united states` — added _(2026-05-12)_ - `locations.dallas va medical center|dallas|texas|united states` — added _(2026-05-12)_ - `locations.pocono medical center|east stroudsburg|pennsylvania|united states` — added _(2026-05-12)_ - `locations.geisinger medical center-cancer center hazleton|hazleton|pennsylvania|united states` — added _(2026-05-12)_ - `locations.lehigh valley hospital-hazleton|hazleton|pennsylvania|united states` — added _(2026-05-12)_ - `locations.geisinger medical oncology-lewisburg|lewisburg|pennsylvania|united states` — added _(2026-05-12)_ - `locations.redeemer health|meadowbrook|pennsylvania|united states` — added _(2026-05-12)_ - `locations.philadelphia veterans administration medical center|philadelphia|pennsylvania|united states` — added _(2026-05-12)_ - `locations.reading hospital mcglinn cancer institute at phoenixville|phoenixville|pennsylvania|united states` — added _(2026-05-12)_ - `locations.pottstown hospital|pottstown|pennsylvania|united states` — added _(2026-05-12)_ - `locations.geisinger cancer services-pottsville|pottsville|pennsylvania|united states` — added _(2026-05-12)_ --- *Canonical: https://parkinsonspathways.com/agent/trials/NCT04871542.md* *Source data (authoritative): https://clinicaltrials.gov/study/NCT04871542* *This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*