---
title: Effectiveness of Adhesive Containing MDPB
nct_id: NCT05118100
overall_status: COMPLETED
sponsor: Radboud University Medical Center
study_type: OBSERVATIONAL
primary_condition: Secondary Caries
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05118100.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05118100"
ct_last_update_post_date: 2021-11-11
last_seen_at: "2026-05-12T07:19:32.635Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effectiveness of Adhesive Containing MDPB

**Official Title:** Effectiveness of Adhesive Containing MDPB: a Practice-based Clinical Trial

**NCT ID:** [NCT05118100](https://clinicaltrials.gov/study/NCT05118100)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 5102
- **Lead Sponsor:** Radboud University Medical Center
- **Conditions:** Secondary Caries
- **Start Date:** 2015-01-01
- **Completion Date:** 2021-06-30
- **CT.gov Last Update:** 2021-11-11

## Brief Summary

9 general practices in the Netherlands were provided with two composite resin adhesives, each for a period of 9 months. One contained MDPB (Adhesive P), and the other one was used as a control (Adhesive S). Patient's age, SES, and caries risk, as well as tooth type/number, reason for restoration placement, used restorative material and bonding agent, and affected surfaces were recorded. All interventions carried out on these teeth in the next 6 years were extracted from the electronic patient records, along with their date, type, reason, and surfaces. Two dependent variables were defined: general failure, and failure due to secondary caries. All data handling and statistical analyses were carried out in R 4.0.5.

## Eligibility

- **Minimum age:** 6 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Needing at least one dental restoration

Exclusion Criteria:

* Opted out of data collection
```

## Arms

- **Protect Bond** — Restoration placed using Clearfil Protect Bond adhesive (Kuraray Noritake, Osaka, Japan) , which contains the antibacterial monomer MDPB (12-Methacryloyloxydodecylpyridiniumbromide)
- **SE Bond** — Restoration placed using Clearfil SEBond adhesive (Kuraray Noritake, Osaka, Japan)

## Interventions

- **Clearfil Protect Bond** (DRUG) — An adhesive is used routinely when placing resin composite restorations. This group receives a commercially available adhesive containing an antibacterial monomer (MDPB)
- **Clearfil SE Bond** (DRUG) — An adhesive is used routinely when placing resin composite restorations. This group receives a commercially available adhesive.

## Primary Outcomes

- **Restoration survival** _(time frame: up to 5 years)_ — Time in years restoration has survived without needing dental re-intervention

## Secondary Outcomes

- **Failure through caries** _(time frame: up to 5 years)_

## Recent Field Changes (last 30 days)

- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05118100.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05118100*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*