---
title: The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy
nct_id: NCT05209958
overall_status: COMPLETED
sponsor: Karadeniz Technical University
study_type: OBSERVATIONAL
primary_condition: C23.550.767.700
countries: Turkey (Türkiye)
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05209958.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05209958"
ct_last_update_post_date: 2022-01-27
last_seen_at: "2026-05-12T07:31:49.985Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# The Effect of Preoperative NLR Level on Epidural Analgesia Application in Thoracotomy

**NCT ID:** [NCT05209958](https://clinicaltrials.gov/study/NCT05209958)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 60
- **Lead Sponsor:** Karadeniz Technical University
- **Conditions:** C23.550.767.700, C23.550.470
- **Start Date:** 2020-06-10
- **Completion Date:** 2022-01-10
- **CT.gov Last Update:** 2022-01-27

## Brief Summary

The aim of this study is to investigate the relationship of preoperative Neutrophil/Lymphocyte Ratio (NLR) with postoperative pain and the effect of preoperative NLR level on timing of epidural analgesia in thoracotomy.

## Detailed Description

The study was conducted prospectively in 60 patients aged 18-75 years, ASA I-III, who underwent thoracotomy. The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28). Each group was divided into subgroups with equal numbers of Prempative analgesia group and control group. Local anesthetic was administered to the preemptive analgesia group (Group P) 20 minutes before the surgical incision through the epidural catheter, and to the control group (Group K) 20 minutes before the patient was awakened from the epidural catheter. NRS levels and additional analgesia needs were recorded at 2, 4, 8, 12 and 24 hours postoperatively.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 75 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Patient graded as American Society of Anesthesiologist (ASA) physical status, I, II or III
* Patient subjected to thoracotomy operation

Exclusion Criteria:

Patient having morbid obesity,

* Patient having renal failure,
* Patient having hepatic failure,
* Patient having neuropsychiatric disease,
* Patient allergy to the study drugs
```

## Arms

- **Group A** — Patients with NLR level below 2
- **Group B** — Patients with NLR level equal to or above 2

## Interventions

- **Neutrophil Lynphosite ratio** (DIAGNOSTIC_TEST) — The patients were divided into 2 groups as NLR level above 2 (Group A) (n:32) and NLR level below 2 (Group B) (n:28).

## Primary Outcomes

- **preoperative neutrophil lymphoycte ratio** _(time frame: 24 hours before the operation)_ — To determine the epidural application with preoperative neutrophil lymphoycte ratio
- **Postoperative opioid requiremen Postoperative opioid requirement** _(time frame: postoperative first 24 hour)_ — Postoperative opioid requirement for pain relief

## Secondary Outcomes

- **Numerical Pain Rating Scale** _(time frame: postoperative first 24 hour)_

## Locations (1)

- KaradenızTU, Trabzon, Turkey (Türkiye)

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.karadenıztu|trabzon||turkey (türkiye)` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05209958*  
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