---
title: Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
nct_id: NCT05338671
overall_status: COMPLETED
phase: PHASE4
sponsor: University of Washington
study_type: INTERVENTIONAL
primary_condition: Endodontic Disease
countries: United States
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05338671.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05338671"
ct_last_update_post_date: 2025-05-29
last_seen_at: "2026-05-12T07:21:39.785Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

**NCT ID:** [NCT05338671](https://clinicaltrials.gov/study/NCT05338671)

## Key Facts

- **Status:** COMPLETED
- **Phase:** PHASE4
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 35
- **Lead Sponsor:** University of Washington
- **Conditions:** Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- **Start Date:** 2021-09-29
- **Completion Date:** 2024-06-01
- **CT.gov Last Update:** 2025-05-29

## Brief Summary

This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.

## Detailed Description

The goal of this study is to assess the efficacy of 2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine in reducing post-operative pain in patients with symptomatic irreversible pulpitis on a mandibular tooth that receive endodontic treatment. Participants of this study will include patients that present to the University of Washington Endodontic clinic and fit the inclusion criteria of being \>18 years old, healthy (ASA I or II) and having a diagnosis of symptomatic irreversible pulpitis on a mandibular tooth, that is willing to undergo endodontic treatment in two visits. Upon diagnosis, and informed consent, patients will be asked to participate in this study. If enrolled in the study, participants will receive standard endodontic treatment with temporary placement of Calcium Hydroxide medicament within the canals of the tooth and placement of a temporary filling. They will then be randomized to receive an inferior alveolar nerve block with 1 cartridge (1.8mL) of either 2% lidocaine 1:100,000 epinephrine or 0.5% bupivicaine 1:200,000 epinephrine. Patients will be given a form to track their pain levels for the next 72 hours, that they will return at a follow up visit. This form will use the Heft-Parker visual analog pain scale to track pain levels as well as ask participants to track their use of over the counter analgesics, in particular, Advil/ibuprofen. The pain tracking form will be returned to the clinic and root canal will be completed also at this follow up visit.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* Diagnosis of symptomatic irreversible pulpitis on mandibular, posterior tooth
* ASA I or II
* \>18 years old

Exclusion Criteria:

* Maxillary or mandibular anterior tooth
* Diagnosis of pulp necrosis or reversible pulpitis
* Tooth deemed non-restorable
* \<18 years old
* ASA III, IV, or V
* Patients who are contraindicated to take ibuprofen
* Patients with allergies to any medications being assessed in this study
```

## Arms

- **2% Lidocaine 1:100,000 epinephrine** (ACTIVE_COMPARATOR) — Participants in this arm will receive an inferior alveolar nerve block with 1 cartridge (1.8 mL) of 2% Lidocaine 1:100,000 epinephrine following endodontic treatment.
- **0.5% bupivicaine 1:200,000 epinephrine** (ACTIVE_COMPARATOR) — Participants in this arm will receive an inferior alveolar nerve block with 1 cartridge (1.8 mL) of 0.5% bupivicaine 1:200,000 epinephrine following endodontic treatment.

## Interventions

- **Local anesthetic** (DRUG) — Patients will receive inferior alveolar nerve block injection following endodontic treatment.

## Primary Outcomes

- **Post-operative Pain Level 6 Hours on a Visual Analog Scale** _(time frame: Patients will be asked to track pain levels at 6 post-operatively on a visual analog scale)_ — Participants will be asked to track the amount of pain they have following their endodontic treatment using the Heft-Parker visual analog scale with scores ranging from 0-170 with higher scores signifying more pain.
- **Post-operative Pain Level 12 Hours on a Visual Analog Scale** _(time frame: Patients will be asked to track pain level at 12 hours post-operatively on a visual analog scale)_ — Participants will be asked to track the amount of pain they have following their endodontic treatment using the Heft-Parker visual analog scale with scores ranging from 0-170 with higher scores signifying more pain.
- **Post-operative Pain Level 24 Hours on a Visual Analog Scale** _(time frame: Patients will be asked to track pain level at 24 hours post-operatively on a visual analog scale)_ — Participants will be asked to track the amount of pain they have following their endodontic treatment using the Heft-Parker visual analog scale with scores ranging from 0-170 with higher scores signifying more pain.
- **Post-operative Pain Level 48 Hours on a Visual Analog Scale** _(time frame: Patients will be asked to track pain level at 48 hours post-operatively on a visual analog scale)_ — Participants will be asked to track the amount of pain they have following their endodontic treatment using the Heft-Parker visual analog scale with scores ranging from 0-170 with higher scores signifying more pain.
- **Post-operative Pain Level 72 Hours on a Visual Analog Scale** _(time frame: Patients will be asked to track pain level at 72 hours post-operatively on a visual analog scale)_ — Participants will be asked to track the amount of pain they have following their endodontic treatment using the Heft-Parker visual analog scale with scores ranging from 0-170 with higher scores signifying more pain.

## Locations (1)

- University of Washington- School of Dentistry, Seattle, Washington, United States

## Recent Field Changes (last 30 days)

- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `locations.university of washington- school of dentistry|seattle|washington|united states` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05338671*  
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