---
title: Comparing of the Clinical Outcome of Periodontal Accelerated Osteogenic Orthodontics With Horizontal or Vertical Releasing Incisions
nct_id: NCT05441683
overall_status: COMPLETED
phase: NA
sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
study_type: INTERVENTIONAL
primary_condition: Malocclusion
countries: China
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05441683.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05441683"
ct_last_update_post_date: 2025-05-11
last_seen_at: "2026-05-12T07:06:25.585Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Comparing of the Clinical Outcome of Periodontal Accelerated Osteogenic Orthodontics With Horizontal or Vertical Releasing Incisions

**Official Title:** Comparison of Vertical Releasing Incisions and Horizontal Extending Incisions for Periodontal Accelerated Osteogenic Orthodontics in the Anterior Region: A Randomized Controlled Trial With Surgical Time, Clinical and Radiographic Outcomes

**NCT ID:** [NCT05441683](https://clinicaltrials.gov/study/NCT05441683)

## Key Facts

- **Status:** COMPLETED
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 22
- **Lead Sponsor:** Second Affiliated Hospital, School of Medicine, Zhejiang University
- **Conditions:** Malocclusion
- **Start Date:** 2022-07-07
- **Completion Date:** 2024-12-30
- **CT.gov Last Update:** 2025-05-11

## Brief Summary

The study aims to compare the effect of periodontal accelerated osteogenic orthodontics (PAOO) with horizontal or vertical releasing incisions on operation time, healing, adverse effects, and effectiveness of bone augmentation.

Methods: A total of 22 patients requiring PAOO surgery due to orthodontic treatment were enrolled in this trial, and randomly divided into test or control group, consisting of 11 subjects in each. The test group will receive PAOO with horizontal extending incisions on both sides of the flap; while the control group will receive PAOO with vertical releasing incisions; the two groups use the same surgical technic except for the incision design. Outcome measures include: operation time, postoperative scar, radiographic data (alveolar height and alveolar ridge thickness), gingival thickness, etc. Clinical evaluation will be performed at 1 week, 2 weeks, 3months, 6 months and 12 months after operation.

## Eligibility

- **Minimum age:** 18 Years
- **Maximum age:** 40 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

1. Patients aged between 18 and 40 years old, systemic healthy, undergoing or planning to undergo orthodontic treatment.
2. Patients with a thin alveolar bone or with dehiscence and/or fenestration on the labial side of maxillary or mandibular front teeth area.
3. Patients with expected tooth movement beyond the labial alveolar bone during orthodontic procedures.

Exclusion Criteria:

1. Smoker.
2. Pregnant or lactating.
3. Untreated periodontitis.
4. Presence of \<2mm keratinized gingival width(KGW) or thin gingival phenotype (as defined by dental probe transparency.)
5. History of orthodontic and/or orthognathic treatment.
6. With systemic disease (diabetes, hypertension, heart disease, malignant tumor, severe mental illness, and other surgical contraindications.)
7. Long-term medication (immunosuppressive drugs, bisphosphonates, etc.)
8. Poor adherence to complete one-year follow-up.
```

## Arms

- **HEI group** (EXPERIMENTAL) — PAOO with horizontal extending incisions on both sides
- **VRI group** (ACTIVE_COMPARATOR) — PAOO with vertical releasing incisions on both sides

## Interventions

- **horizontal extending incision** (PROCEDURE) — a papilla preserving incision will be made on the labial side of the front teeth with a thin alveolar bone or dehiscence and/or fenestration. Then horizontally extending incisions will be added to each side of the initial incision, extending one to two teeth beyond the defected area, before a full-thickness flap is lifted.
- **vertical releasing incision** (PROCEDURE) — a papilla preserving incision will be made on the labial side of the front teeth with a thin alveolar bone or dehiscence and/or fenestration. Vertical releasing incisions will be made on each side of the initial incision before a full-thickness flap is lifted. The incision formed an oblique trapezoidal flap with a wider base.

## Primary Outcomes

- **Surgery Time** _(time frame: 1 day)_ — Timing will start when the first incision is about to be made, and end when the last suture is complete. The time in between will be recorded as surgery time.

## Secondary Outcomes

- **Probing Depth (PD)** _(time frame: 12 months)_
- **Clinical Attachment Level (CAL)** _(time frame: 12 months)_
- **Keratinized Gingival Width (KGW)** _(time frame: 12 months)_
- **Gingival Recession Depth (GRD)** _(time frame: 12 months)_
- **Root Length** _(time frame: 12 months)_
- **Vertical Bone Height (VBL)** _(time frame: 12 months)_
- **Alveolar Bone Width Measured at 2 mm Below the CEJ (BW2)** _(time frame: 12 months)_
- **Alveolar Bone Width Measured at 4 mm Below the CEJ (BW4)** _(time frame: 12 months)_
- **Alveolar Bone Width Measured at 6 mm Below the CEJ (BW6)** _(time frame: 12 months)_
- **Number of Participants With Visible Scarring** _(time frame: 12 months)_
- **Pain Level** _(time frame: 2 weeks)_
- **Membrane Exposure** _(time frame: 2 weeks)_
- **Facial Swelling** _(time frame: 2 weeks)_
- **Mucosal Color** _(time frame: 2 weeks)_
- **Mucosa Edema** _(time frame: 2 weeks)_

## Locations (1)

- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.2nd affiliated hospital, school of medicine, zhejiang university|hangzhou|zhejiang|china` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05441683.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05441683*  
*This page is a raw mirror with no AI summary, no editorial enrichment, and no Parkinson's-specific filtering.*