---
title: Transmuscular Quadratus Lumborum Block on Post-Operative Analgesia After Total Hip Arthroplasty
nct_id: NCT05465967
overall_status: UNKNOWN
phase: NA
sponsor: Tanta University
study_type: INTERVENTIONAL
primary_condition: Quadratus Lumborum Block
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05465967.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05465967"
ct_last_update_post_date: 2022-07-26
last_seen_at: "2026-05-12T06:32:05.973Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Transmuscular Quadratus Lumborum Block on Post-Operative Analgesia After Total Hip Arthroplasty

**Official Title:** A Comparative Study Between Two Approaches of Ultrasound-Guided Transmuscular Quadratus Lumborum Block on Post-Operative Analgesia After Total Hip Arthroplasty

**NCT ID:** [NCT05465967](https://clinicaltrials.gov/study/NCT05465967)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 75
- **Lead Sponsor:** Tanta University
- **Conditions:** Quadratus Lumborum Block
- **Start Date:** 2021-09-01
- **Completion Date:** 2022-09-01
- **CT.gov Last Update:** 2022-07-26

## Brief Summary

The aim of this study is to compare between the post-operative analgesic effect of two approaches of transmuscular quadratus lumborum block (transverse versus paraspinous sagittal transmuscular QLB) in total hip replacement surgery.

## Detailed Description

During the preanesthetic assessment, all patients will be educated about the visual analogue scale (VAS) for pain assessment, with scores ranging from 0 to 10 (0 represent no pain, while10 represent maximum intolerable pain).

The patients will be randomly classified into three equal groups (25 patients each). Group allocation will be done by computer generated random numbers and closed opaque sealed envelopes. The study will be designed to be double blind as all patients and postoperative assessor will be blinded to group assignment.

Patients will be randomized to one of three equal groups:

* Group I: Control group (n= 25 patients): Patients in this group will receive ipsilateral sham ultrasound-guided block via subcutaneous injection of 1 ml of normal saline after surgery.
* Group II (n= 25 patients): Patients in this group will receive an ipsilateral single shot of transverse transmuscular approach of QLB (30 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.
* Group III (n= 25 patients): patients in this group will receive an ipsilateral single-shot of paraspinous sagittal approach of QLB (30 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.

## Eligibility

- **Minimum age:** 21 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

* 75 patients, aged between 21- 80 years old, of both sex American society of Anesthesiology I - III scheduled for total hip replacement surgery.

Exclusion Criteria:

* Patient refusal.
* Coagulopathy
* Spinal deformities
* Peripheral neuropathy; sensory disorders in the leg requiring surgery and chronic pain.
* Mental dysfunction, psychiatric illnesses and cognitive dysfunction.
* History of drug abuse \&chronic analgesic use
```

## Arms

- **Group I: Control Group** (SHAM_COMPARATOR) — Patients in this group will receive ipsilateral sham ultrasound-guided block via subcutaneous injection of 1 ml of normal saline after surgery.
- **Group II:( transverse trans muscular Quadratus lumborum group).** (ACTIVE_COMPARATOR) — patients in this group will receive an ipsilateral single-shot of paraspinous sagittal approach of Quadratus lumborum BLOCK(30 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.
- **Group III : paraspinous sagittal approach of Quadratus lumborum BLOCK** (ACTIVE_COMPARATOR) — patients in this group will receive an ipsilateral single-shot of paraspinous sagittal approach of Quadratus lumborum BLOCK (30 ml of plain bupivacaine 0.25%) after surgery using ultrasonographic guidance.

## Interventions

- **Quadratus lumborum Block** (PROCEDURE) — 1-Transverse transmuscular Quadratus lumborum block: ultrasound transducer will placed transverse to the abdominal flank to visualise abdominal muscle layers. moving the probe posteriorly, the transverse process of the lumbar vertebra, Quadratus lumborum, Psoas Major and erector spinae muscles identified as a 'Shamrock sign'. the needle will inserted through the back muscles to fascial plane between the Quadratus lumborum and Psoas Major, local anesthetic will injected .2- paraspinous sagittal Quadratus lumborum block: ultrasound transducer will be directed caudally in a sagittal plane lateral to the spinous process of L4. moving laterally until the Quadratus lumborum is evident in its long axis with a characteristic sonographic image of three muscle layers appearing from posterior to anterior as: erector spinae, Quadratus lumborum, and Psoas major muscle the needle will be advanced through the muscles, until it pierces the Quadratus lumborum. local anesthetic will be injected.

## Primary Outcomes

- **Postoperative morphine consumption** _(time frame: Baseline)_ — Total Morphine consumption in the first 24 h of the post-operative period .

## Secondary Outcomes

- **Postoperative pain score** _(time frame: Baseline)_

## Locations (1)

- Tanata university hospital, Tanta, Egypt — _RECRUITING_

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.tanata university hospital|tanta||egypt` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05465967*  
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