---
title: Comparison of Liagure Safety in Thyroidectomy With Conventional Thyroidectomy
nct_id: NCT05684536
overall_status: UNKNOWN
phase: NA
sponsor: Imam Mohammad ibn Saud Islamic University
study_type: INTERVENTIONAL
primary_condition: Ligature; Hemorrhage
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05684536.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05684536"
ct_last_update_post_date: 2023-01-13
last_seen_at: "2026-05-12T06:33:26.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Comparison of Liagure Safety in Thyroidectomy With Conventional Thyroidectomy

**NCT ID:** [NCT05684536](https://clinicaltrials.gov/study/NCT05684536)

## Key Facts

- **Status:** UNKNOWN
- **Phase:** NA
- **Study Type:** INTERVENTIONAL
- **Target Enrollment:** 20
- **Lead Sponsor:** Imam Mohammad ibn Saud Islamic University
- **Conditions:** Ligature; Hemorrhage, Recurrent Laryngeal Nerve Injuries, Hypocalcemia
- **Start Date:** 2023-01-15
- **Completion Date:** 2023-04-01
- **CT.gov Last Update:** 2023-01-13

## Brief Summary

To compare intraoperative and postoperative complication rates in thyroidectomy between ligasure and traditional vascular ligation and clipping .

## Detailed Description

Due to the high vascularity of the thyroid gland and the relatively tiny operative field, rigorous hemostasis is an essential requirement for successful thyroid surgery. Blood vessel ligation and/or ligation are the primary means of attaining hemostasis in thyroidectomy. New technologies have been developed, including a vessel sealing device (ligasure) that seals vessels by fusing the inner layers of the vessel wall with minimal amounts of thermal dispersion burning and tissue friction, thereby minimizing the occurrence of unintentional burns.

yet. It is unclear whether the heat conveyed by a ligature can harm the recurrent laryngeal nerve due to its proximity to the berry ligament.

thromosis of the inferior parathyroidal gland's supplying artery during dissection may result from alternative prospective delineation of the inferior thyroidal artery using ligasure for dissection.

The purpose of this study is to assess the safety and efficacy of ligasure with standard vascular ligation in open thyroid surgery.

## Eligibility

- **Minimum age:** 12 Years
- **Maximum age:** 80 Years
- **Sex:** ALL
- **Healthy Volunteers:** Yes

```
Inclusion Criteria:

Patient who will undergo lobectomy , subtotal thyroidectomy , total thyroidectomy at time of study

Any age

\-

Exclusion Criteria:

* patient undergoing re-do surgery " completion thyroidectomy "

patient undergoing concomitant procedures as cervical lymphadenectomy or parathyroidectomy
```

## Arms

- **ligasure throidectomy** (ACTIVE_COMPARATOR) — the vessel sealing device ( ligasure covidien ) which seals vessels by fusing the inner layers of the vessel wall, with dissection around ligament of berry and inferior thyroidal artery
- **conventional thyroidectomy** (NO_INTERVENTION) — with dissection around ligament of berry and inferior thyroidal artery through ligation with vicryl and hemoclips

## Interventions

- **liagsure device** (DEVICE) — the vessel sealing device ( ligasure covidien ) which seals vessels by fusing the inner layers of the vessel wall, with dissection around ligament of berry and inferior thyroidal artery

## Primary Outcomes

- **Post-operative complications** _(time frame: Postoperatively from day of surgery until one week post operatively)_ — Including RLN palsy , hypocalcemia , hemorrhage wound infection

## Recent Field Changes (last 30 days)

- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.phases` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `status.overallStatus` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.maxAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `armsInterventions.interventions` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_

---

*Canonical: https://parkinsonspathways.com/agent/trials/NCT05684536.md*  
*Source data (authoritative): https://clinicaltrials.gov/study/NCT05684536*  
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