---
title: Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis
nct_id: NCT05706493
overall_status: COMPLETED
sponsor: Misr International University
study_type: OBSERVATIONAL
primary_condition: Periodontal Diseases
countries: Egypt
canonical_url: "https://parkinsonspathways.com/agent/trials/NCT05706493.md"
clinicaltrials_gov: "https://clinicaltrials.gov/study/NCT05706493"
ct_last_update_post_date: 2026-01-13
last_seen_at: "2026-05-12T07:26:40.085Z"
source: ClinicalTrials.gov (mirrored, no enrichment)
---
# Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis

**Official Title:** Association Between Severity of Periodontitis and the Level of Anti-citrullinated Protein Antibodies (ACPAs) in Rheumatoid Arthritis Patients

**NCT ID:** [NCT05706493](https://clinicaltrials.gov/study/NCT05706493)

## Key Facts

- **Status:** COMPLETED
- **Study Type:** OBSERVATIONAL
- **Target Enrollment:** 36
- **Lead Sponsor:** Misr International University
- **Conditions:** Periodontal Diseases, Rheumatoid Arthritis
- **Start Date:** 2024-03-01
- **Completion Date:** 2025-02-01
- **CT.gov Last Update:** 2026-01-13

## Brief Summary

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients

## Detailed Description

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics.

The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid before and after non-surgical periodontal treatment and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients Materials and Methods: a total of 40 participants suffering from periodontitis and rheumatoid arthritis will be referred from the Badr Hospital (Faculty of Medicine, Helwan University) to Misr international university's dental clinic complex. Gingival crevicular fluid (GCF) samples will be collected from the patients before performing periodontal therapy (baseline). Assessment of ACPAs will be quantified using enzyme-linked immunoassay (ELISA) as the primary outcome at baseline and after 3 months. Assessment of 2ry outcomes includes clinical periodontal and RA parameters at baseline and after 3 months.

## Eligibility

- **Minimum age:** 18 Years
- **Sex:** ALL
- **Healthy Volunteers:** No

```
Inclusion Criteria:

* Rheumatoid patients fulfilling the ACR criteria for the classification of RA

  * 18 years
* Both genders
* Presence of at least 8 teeth

Exclusion Criteria:

* Smoking
* Diabetes Mellitus
* Pregnant females
* Patients who had undergone periodontal treatment within last 3 months
* Antibiotic therapy during last 3 months
* Other autoimmune diseases
```

## Arms

- **Non-surgical periodontal treatment** — assessment of different periodontal parameters and gingival crevicular fluid sampling will be done then non surgical periodontal treatment will be performed then after 3 months re assessment of the periodontal parameters and gingival crevicular fluid sampling will be done

## Primary Outcomes

- **Change in the level of anti-citrullinated protein antibodies (ACPAs)** _(time frame: at baseline and 3 months)_ — assessment of the level of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid

## Secondary Outcomes

- **Change in Clinical attachment Loss** _(time frame: at baseline and 3 months)_
- **Change in Probing depth** _(time frame: at baseline and 3 months)_
- **Change in Plaque index (PI)** _(time frame: at baseline and 3 months)_

## Locations (1)

- Faculty of oral and dental medicine, Misr international university, Cairo, Egypt

## Recent Field Changes (last 30 days)

- `status.overallStatus` — added _(2026-05-12)_
- `status.primaryCompletionDate` — added _(2026-05-12)_
- `status.completionDate` — added _(2026-05-12)_
- `status.lastUpdatePostDate` — added _(2026-05-12)_
- `design.enrollmentCount` — added _(2026-05-12)_
- `eligibility.criteria` — added _(2026-05-12)_
- `eligibility.minAge` — added _(2026-05-12)_
- `eligibility.sex` — added _(2026-05-12)_
- `outcomes.primary` — added _(2026-05-12)_
- `outcomes.secondary` — added _(2026-05-12)_
- `armsInterventions.arms` — added _(2026-05-12)_
- `sponsor.lead` — added _(2026-05-12)_
- `results.hasResults` — added _(2026-05-12)_
- `locations.faculty of oral and dental medicine, misr international university|cairo||egypt` — added _(2026-05-12)_

---

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*Source data (authoritative): https://clinicaltrials.gov/study/NCT05706493*  
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